Table 3.
The most impactful LTCs combinations in stratified logistic regression analysis for mortality, for different multimorbidity categories (based on LTC count)
| Categories | No. of deaths | No. of person-years | Mortality ratea | Adjustedb OR (95% CI) |
|---|---|---|---|---|
| 2 LTCs (Total number of deaths N = 1146) | ||||
| Hypertension + diabetes | 570 | 26,753.84 | 21.31 | 1.89 (1.67,2.13) |
| Hypertension + CHD | 416 | 21,575.80 | 19.28 | 1.44 (1.26,1.64) |
| Hypertension + stroke | 58 | 1581.35 | 36.68 | 2.41 (1.75,3.32) |
| Hypertension + COPD | 44 | 992.24 | 44.34 | 3.02 (2.12,4.31) |
| Diabetes + CHD | 28 | 2162.11 | 12.95 | 1.15 (0.77,1.72) |
| CHD + COPD | 11 | 312.92 | 35.15 | 2.02 (1.03,3.95) |
| Hypertension + Mental disorders | 8 | 284.27 | 28.14 | 2.08 (0.92,4.70) |
| Diabetes + COPD | 4 | 89.62 | 44.63 | 4.04 (1.29,12.71) |
| 3 LTCs (Total number of deaths N = 279) | ||||
| Hypertension + diabetes + CHD | 188 | 8849.08 | 21.25 | 1.90 (1.59,2.27) |
| Hypertension + diabetes + stroke | 29 | 660.92 | 43.88 | 3.48 (2.29,5.28) |
| Hypertension + stroke + CHD | 17 | 652.11 | 26.07 | 2.09 (1.23,3.54) |
| Hypertension + CHD + COPD | 17 | 477.75 | 35.58 | 2.57 (1.50,4.41) |
| Hypertension + diabetes + COPD | 9 | 294.51 | 30.56 | 2.44 (1.16,5.11) |
| 4 LTCs (Total number of deaths N = 18) | ||||
| Hypertension + diabetes +stroke + CHD | 9 | 274.78 | 32.75 | 3.18 (1.52,6.65) |
All predictors entered individually in separate models using No LTC group as the reference category
LTCs Long-term conditions, CHD Coronary heart disease, COPD Chronic obstructive pulmonary disease, OR (95% CI) Odds ratio and 95% confidence interval
aPer 1000 person-years; bAdjusted for age, sex, marital status, smoking status, alcohol status, physical activity, and body mass index (< 18.5, 18.5–24.9, 25–29.9, 30–34.9, 35–39.9 or ≥ 40) at baseline