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. 2021 Jun 5;9:44. doi: 10.1186/s40364-021-00299-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Ranking order of E-Cadherin immunostaining in tumors. a Tumor types and subtypes with positive (orange dots) staining (n = 101), b tumor types and subtypes from E-Cadherin positive normal cells with negative (orange dots) and negative to weak (blue dots) immunostaining (n = 60; not shown: 17 tumor types without E-Cadherin loss), and c tumor types and subtypes from E-Cadherin negative normal cells with positive (orange dots) and moderate to strong (blue dots) immunostaining (n = 24, not shown: 5 tumor types without E-Cadherin staining)