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. 2021 Jun 5;18:126. doi: 10.1186/s12974-021-02176-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — CSF cytokine levels in Cx43 icKO and Cx43^fl/fl mice in the onset phase of EAE. a Mouse CSF was withdrawn from the foramen magna in the onset phase (dpi 10) of EAE and analyzed by a multiplexed fluorescence immunoassay. Each bar represents the mean cytokine level ± SEM (n = 3). Data were statistically analyzed by two-way ANOVA, followed by Sidak’s multiple comparison tests. *P < 0.05, ***P < 0.001. b Heat map of dual cluster analysis: cytokine levels and mice. A horizontal label represents individual mice. Cx43^fl/fl mice are indicated in red and Cx43 icKO mice are indicated in blue. The ranges for measured cytokine levels are shown in parentheses. GM-CSF granulocyte-macrophage colony-stimulating factor, IFN interferon, IL interleukin, TNF tumor necrosis factor