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. 2021 Mar 6;8(6):ofab104. doi: 10.1093/ofid/ofab104

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© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — (A) A heat map comparing Pediatric Infectious Disease Precision Medicine Using Sequencing Evaluation of CSF (PIPSEC) subjects with bacterial and viral diagnoses identified 409 differentially expressed genes with false discovery rate >0.05 and fold change ≥1.5. (B) Volcano plot identifying differentially expressed genes between bacterial and viral meningitis. (C) Scatter plot depicting mean, standard error of the mean, and individual values. **P-adjusted value (p-adj) < .01, ***p-adj < .0001 compared with all other groups with a fold change of 10.0 for interleukin (IL)1B and 18.0 for CXCL8 in bacterial meningitis, and 14.0 for CCL8 in viral meningitis compared with all other samples. (D) Receiver operator characteristic (ROC) for IL1B and CCL8. AUC, area under curve.