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. 2021 Jun 2;13:4433–4445. doi: 10.2147/CMAR.S295147

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© 2021 Yuan et al.

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MiR-760 overexpression repressed DXR resistance in DXR-resistant OS cells by binding to EZH2. KHOS/DXR and MG63/DXR cells were transfected with miR-NC, miR-760, miR-760+pcDNA or miR-760+EZH2. (A) IC50 of DXR in KHOS/DXR and MG63/DXR cells was assessed by CCK-8 assay. (B) The colony formation of KHOS/DXR and MG63/DXR cells was investigated by colony formation assay. (C–E) The migration and invasion of KHOS/DXR and MG63/DXR cells were assessed by wound-healing assay and transwell assay. (F) The apoptosis of KHOS/DXR and MG63/DXR cells was analyzed by flow cytometry analysis. (G and H) The protein levels of MRP1, P-gp and LRP in c were measured via Western blot assay. *P<0.05.