Table 2.
Characteristics of the SNPs Associated with BMI and Their Associations with Osteoarthritis
| SNPs | Chr | Gene | EA | EAF | BMI | Osteoarthritis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | P | β | SE | P | |||||
| rs1000940 | 17:5379957 | RABEP1 | G | 0.23 | 0.0184 | 0.0033 | 1.81E-08 | 0.0003 | 0.0006 | 0.61 |
| rs10132280 | 14:25458973 | STXBP6 | A | 0.33 | −0.0221 | 0.0033 | 1.40E-11 | −0.0009 | 0.0006 | 0.17 |
| rs1016287 | 2:59078490 | LINC01122 | T | 0.33 | 0.0228 | 0.0033 | 4.36E-12 | 0.0008 | 0.0006 | 0.18 |
| rs10182181 | 2:24927427 | ADCY3 | A | 0.50 | −0.0309 | 0.0029 | 8.07E-26 | −0.0013 | 0.0006 | 0.02 |
| rs10733682 | 9:126698635 | LMX1B | A | 0.43 | 0.0188 | 0.0030 | 2.46E-10 | 0.0008 | 0.0006 | 0.20 |
| rs10840100 | 11:8647890 | TRIM66 | G | 0.73 | 0.0206 | 0.0030 | 6.67E-12 | 0.0011 | 0.0006 | 0.06 |
| rs11030104 | 11:27662970 | BDNF | A | 0.80 | 0.0416 | 0.0037 | 6.66E-30 | 0.0029 | 0.0007 | <0.001 |
| rs11057405 | 12:122297350 | CLIP1 | A | 0.09 | −0.0304 | 0.0053 | 1.22E-08 | −0.0009 | 0.0009 | 0.36 |
| rs11165643 | 1:96458541 | PTBP2 | C | 0.43 | −0.0221 | 0.0030 | 1.43E-13 | −0.0005 | 0.0006 | 0.40 |
| rs11672660 | 19:45676926 | GIPR, MIR642B | C | 0.83 | 0.0339 | 0.0038 | 7.91E-19 | 0.0009 | 0.0007 | 0.19 |
| rs1167827 | 7:75533848 | HIP1 | A | 0.46 | −0.0200 | 0.0031 | 1.98E-10 | 0.0000 | 0.0006 | 0.96 |
| rs11727676 | 4:144737912 | HHIP | C | 0.08 | −0.0365 | 0.0063 | 6.25E-09 | 0.0018 | 0.0010 | 0.07 |
| rs12286929 | 11:115151684 | CADM1 | G | 0.43 | 0.0211 | 0.0029 | 5.44E-13 | −0.0001 | 0.0006 | 0.92 |
| rs12429545 | 13:53528071 | OLFM4 | G | 0.90 | −0.0324 | 0.0044 | 3.15E-13 | −0.0011 | 0.0009 | 0.19 |
| rs12448257 | 16:3549655 | NLRC3, LOC101929732 |
G | 0.78 | −0.0246 | 0.0037 | 3.90E-11 | −0.0001 | 0.0007 | 0.93 |
| rs12940622 | 17:80641771 | RPTOR | A | 0.46 | −0.0183 | 0.0029 | 3.64E-10 | −0.0002 | 0.0006 | 0.73 |
| rs12986742 | 2:58748008 | LINC01122 | C | 0.50 | 0.0207 | 0.0036 | 8.92E-09 | 0.0003 | 0.0006 | 0.63 |
| rs13021737 | 2:632348 | TMEM18 | A | 0.13 | −0.0604 | 0.0039 | 5.44E-54 | −0.0026 | 0.0008 | <0.001 |
| rs13078960 | 3:85758440 | CADM2 | T | 0.82 | −0.0290 | 0.0038 | 1.42E-14 | −0.0010 | 0.0007 | 0.15 |
| rs13107325 | 4:102267552 | SLC39A8 | C | 0.88 | −0.0472 | 0.0066 | 1.06E-12 | −0.0096 | 0.0011 | <0.001 |
| rs13130484 | 4:45173674 | / | C | 0.57 | −0.0398 | 0.0030 | 8.01E-41 | −0.0011 | 0.0006 | 0.06 |
| rs13191362 | 6:162612318 | PRKN | A | 0.80 | 0.0285 | 0.0047 | 1.09E-09 | −0.0003 | 0.0009 | 0.70 |
| rs13201877 | 6:137354404 | LOC107986544 | A | 0.92 | −0.0236 | 0.0043 | 4.29E-08 | 0.0005 | 0.0008 | 0.55 |
| rs13329567 | 15:67812029 | / | T | 0.22 | −0.0307 | 0.0035 | 1.53E-18 | −0.0013 | 0.0007 | 0.06 |
| rs1421085 | 16:53767042 | FTO | C | 0.45 | 0.0803 | 0.0030 | 2.17E-158 | 0.0013 | 0.0006 | 0.03 |
| rs1441264 | 13:79006784 | MR548A2 | A | 0.55 | 0.0172 | 0.0031 | 2.96E-08 | −0.0001 | 0.0006 | 0.89 |
| rs1460676 | 2:163711179 | FIGN | T | 0.78 | −0.0209 | 0.0038 | 4.98E-08 | −0.0006 | 0.0008 | 0.46 |
| rs14810 | 19:33813998 | KCTD15 | C | 0.33 | −0.0183 | 0.0033 | 1.92E-08 | −0.0011 | 0.0006 | 0.06 |
| rs1516725 | 3:186106215 | ETV5 | T | 0.09 | −0.0448 | 0.0044 | 1.39E-24 | −0.0023 | 0.0008 | 0.01 |
| rs1528435 | 2:180686235 | UBE2E3 | T | 0.58 | 0.0175 | 0.0030 | 4.77E-09 | 0.0006 | 0.0006 | 0.27 |
| rs16851483 | 3:141556594 | RASA2 | G | 0.91 | −0.0478 | 0.0075 | 1.85E-10 | −0.0029 | 0.0012 | 0.01 |
| rs17001654 | 4:76208415 | SCARB2 | C | 0.84 | −0.0304 | 0.0052 | 5.03E-09 | −0.0014 | 0.0008 | 0.08 |
| rs17066856 | 18:60382423 | / | C | 0.13 | −0.0371 | 0.0050 | 2.00E-13 | 0.0008 | 0.0010 | 0.42 |
| rs17094222 | 10:100635683 | HIF1AN | C | 0.21 | 0.0249 | 0.0037 | 2.19E-11 | 0.0005 | 0.0007 | 0.49 |
| rs17203016 | 2:207390794 | CREB1;KLF7 | G | 0.20 | 0.0211 | 0.0038 | 3.41E-08 | 0.0004 | 0.0007 | 0.57 |
| rs17381664 | 1:77582646 | ZZZ3 | C | 0.43 | 0.0201 | 0.0031 | 4.57E-11 | 0.0006 | 0.0006 | 0.34 |
| rs17724992 | 19:18344015 | PGPEP1 | A | 0.69 | 0.0196 | 0.0034 | 7.79E-09 | 0.0006 | 0.0006 | 0.33 |
| rs1928295 | 9:117616205 | TLR4 | C | 0.43 | −0.0182 | 0.0029 | 4.32E-10 | −0.0007 | 0.0006 | 0.22 |
| rs2033529 | 6:40380914 | TDRG1;LRFN2 | G | 0.26 | 0.0183 | 0.0032 | 1.45E-08 | 0.0003 | 0.0006 | 0.58 |
| rs2060604 | 8:75738099 | / | T | 0.56 | 0.0203 | 0.0030 | 9.46E-12 | −0.0007 | 0.0006 | 0.25 |
| rs2112347 | 5:75719417 | POC5, LOC441087 | G | 0.38 | −0.0254 | 0.0030 | 1.96E-17 | 0.0009 | 0.0006 | 0.14 |
| rs2176598 | 11:43842728 | HSD17B12 | T | 0.20 | 0.0185 | 0.0033 | 3.47E-08 | 0.0011 | 0.0007 | 0.08 |
| rs2183825 | 9:28412377 | LINGO2 | C | 0.29 | 0.0241 | 0.0032 | 2.22E-14 | 0.0010 | 0.0006 | 0.11 |
| rs2365389 | 3:61250788 | FHIT | C | 0.66 | 0.0195 | 0.0030 | 1.35E-10 | 0.0005 | 0.0006 | 0.36 |
| rs2820292 | 1:201815159 | NAV1, IPO9AS1 | A | 0.49 | −0.0181 | 0.0029 | 5.45E-10 | −0.0014 | 0.0006 | 0.02 |
| rs2836754 | 21:38919816 | LOC400867 | C | 0.65 | 0.0169 | 0.0030 | 1.61E-08 | 0.0016 | 0.0006 | 0.01 |
| rs2890652 | 2:142202362 | / | T | 0.88 | −0.0279 | 0.0049 | 1.24E-08 | 0.0003 | 0.0008 | 0.73 |
| rs3736485 | 15:51456413 | DMXL2 | A | 0.43 | 0.0160 | 0.0029 | 4.52E-08 | 0.0017 | 0.0006 | <0.001 |
| rs3800229 | 6:108675760 | FOXO3 | T | 0.69 | 0.0175 | 0.0032 | 4.95E-08 | 0.0006 | 0.0006 | 0.33 |
| rs3817334 | 11:47629441 | MTCH2 | C | 0.55 | −0.0256 | 0.0030 | 1.17E-17 | 0.0003 | 0.0006 | 0.60 |
| rs3849570 | 3:81742961 | GBE1 | A | 0.37 | 0.0183 | 0.0033 | 1.93E-08 | 0.0012 | 0.0006 | 0.04 |
| rs3888190 | 16:28878165 | ATP2A1 | A | 0.36 | 0.0311 | 0.0030 | 3.45E-25 | 0.0007 | 0.0006 | 0.23 |
| rs4740619 | 9:15634328 | CCDC171 | T | 0.53 | 0.0170 | 0.0029 | 6.36E-09 | 0.0010 | 0.0006 | 0.08 |
| rs4889606 | 16:30999862 | STX1B | G | 0.36 | −0.0187 | 0.0030 | 6.58E-10 | −0.0004 | 0.0006 | 0.54 |
| rs543874 | 1:177920345 | SEC16B | G | 0.27 | 0.0497 | 0.0037 | 2.29E-40 | 0.0009 | 0.0007 | 0.19 |
| rs6091540 | 20:52471323 | LOC105372666, LOC105372667 | C | 0.73 | 0.0185 | 0.0033 | 2.14E-08 | 0.0009 | 0.0006 | 0.13 |
| rs6457796 | 6:34860776 | UHRF1BP1 | T | 0.74 | −0.0209 | 0.0033 | 2.54E-10 | −0.0025 | 0.0006 | <0.001 |
| rs6477694 | 9:109170062 | EPB41L4B | C | 0.36 | 0.0169 | 0.0030 | 1.71E-08 | 0.0012 | 0.0006 | 0.04 |
| rs6567160 | 18:60161902 | MC4R | C | 0.28 | 0.0562 | 0.0035 | 6.68E-59 | 0.0017 | 0.0007 | 0.01 |
| rs657452 | 1:49124175 | AGBL4 | A | 0.42 | 0.0227 | 0.0031 | 2.12E-13 | 0.0004 | 0.0006 | 0.55 |
| rs6713510 | 2:226169783 | LOC646736 | A | 0.48 | 0.0164 | 0.0029 | 1.97E-08 | −0.0007 | 0.0006 | 0.22 |
| rs6804842 | 3:25064946 | RARB | A | 0.43 | −0.0183 | 0.0030 | 8.02E-10 | −0.0007 | 0.0006 | 0.25 |
| rs7138803 | 12:49853685 | BCDIN3D, FAIM2 | G | 0.56 | −0.0320 | 0.0030 | 5.12E-26 | −0.0013 | 0.0006 | 0.03 |
| rs7144011 | 14:79474040 | NRXN3 | T | 0.28 | 0.0274 | 0.0035 | 6.05E-15 | 0.0008 | 0.0007 | 0.26 |
| rs7531118 | 1:72371556 | LOC105378797 | T | 0.39 | −0.0331 | 0.0030 | 1.88E-28 | −0.0012 | 0.0006 | 0.04 |
| rs7550711 | 1:109540264 | GPR61 | T | 0.03 | 0.0659 | 0.0087 | 5.06E-14 | 0.0003 | 0.0018 | 0.85 |
| rs7599312 | 2:212548507 | LOC107985979 | G | 0.71 | 0.0214 | 0.0033 | 4.73E-11 | 0.0001 | 0.0007 | 0.88 |
| rs7715256 | 5:154158333 | GALNT10 | G | 0.45 | 0.0168 | 0.0029 | 8.85E-09 | −0.0001 | 0.0006 | 0.80 |
| rs7899106 | 10:85651147 | GRID1 | A | 0.95 | −0.0379 | 0.0067 | 1.27E-08 | 0.0001 | 0.0013 | 0.92 |
| rs7903146 | 10:112998590 | TCF7L2 | T | 0.25 | −0.0235 | 0.0033 | 1.10E-12 | −0.0004 | 0.0006 | 0.49 |
| rs879620 | 16:3965728 | ADCY9 | C | 0.41 | −0.0244 | 0.0039 | 3.94E-10 | 0.0006 | 0.0006 | 0.30 |
| rs891389 | 18:23507567 | NPC1, RMC1 | C | 0.68 | −0.0209 | 0.0037 | 1.62E-08 | −0.0012 | 0.0006 | 0.05 |
| rs9304665 | 19:47099320 | ZC3H4 | A | 0.70 | 0.0243 | 0.0043 | 1.59E-08 | 0.0003 | 0.0007 | 0.66 |
| rs9374842 | 6:119864519 | LOC285762 | T | 0.74 | 0.0196 | 0.0034 | 7.20E-09 | 0.0010 | 0.0007 | 0.16 |
| rs943005 | 6:50898107 | / | T | 0.10 | 0.0444 | 0.0038 | 4.52E-31 | 0.0006 | 0.0008 | 0.43 |
| rs9540493 | 13:65631572 | MIR548X2, PCDH9 | G | 0.55 | −0.0182 | 0.0031 | 3.95E-09 | 0.0001 | 0.0006 | 0.93 |
| rs9579083 | 13:27443133 | MTIF3 | G | 0.77 | −0.0295 | 0.0046 | 1.43E-10 | 0.0002 | 0.0007 | 0.79 |
| rs977747 | 1:47219005 | TAL1 | T | 0.47 | 0.0168 | 0.0030 | 2.18E-08 | 0.0005 | 0.0006 | 0.43 |
| rs9926784 | 16:19930646 | / | T | 0.79 | 0.0249 | 0.0038 | 8.55E-11 | 0.0009 | 0.0007 | 0.23 |
Abbreviations: BMI, body mass index; EA, effect allele; EAF, effect allele frequency; SE, standard error; SNP, single-nucleotide polymorphism.