Table 2.

INVEST in Bone Health Trial Assessment Timeline

INVEST Measurements	SV1	SV1A	SV2	SV3	INT	FV1	FV2	INT	FV3	FV4
Participant Status	fasted			fasted			fasted			fasted
Weeks	−6 to 0				1-24	22-26		25-52	50-54
Location	WFSM or WFU	Phone	WFU	WFSM	WFSM or WFU	WFU	WFSM	WFSM or WFU	WFU	WFSM
Questionnaires
Phone Screener
Consent/HIP AA	•
Demographics	•
Medical history	•	•
Medications	•	•	•	••		•	••		•	••
Depression (CES-D)	•	•		••			••			••
Cognitive Assessment (MoCA)	•									•
Pittsburgh Fatigability Scale				••			••			••
PROMIS Pain Intensity and				••			••			••
Fatigue
CHAMPS physical activity	•	•		••			••			••
Adverse Events			•	••	••	•	••	••	•	••
Physical Exams and Physical Performance Measures
Vital signs		•		•		•	•		•	•
Anthropometrics				•		•			•
eSPPB				•		•			•
Hand Grip Test				•		•			•
RMR					•		•			•
Activity Monitor - thigh				•		•			•
Activity Monitor - in vest								•
400-meter Walk – fast				•		•			•
TUG				•		•			•
Biodex					•		•			•
Stair climb				•		•			•
Musculoskeletal Assessments
DXA			•			•			•
QCT				•			•			•
D3Cr Muscle mass				•			•			•
Phlebotomy
CBC	•
Metabolic Panel	•
Vitamin D				•
Plasma/Serum Storage				•		•				•
Other
Run-in instructions	•		•
Participant Satisfaction								••		••
Self-Efficacy					••			••		••
Adherence monitoring					•			•

SV=screening visit, INT=intervention, FV=follow up visit, WFSM=Wake Forest School of Medicine, WFU=Wake Forest University, eSPPB=extended short physical performance battery, RMR=resting metabolic rate, TUG=timed up and go, DXA=dual energy x-ray absorptiometry, QCT=computed tomography, D₃C_r-Deuterated creatine dilution method for directly measuring muscle mass, CBC=complete blood count. Occurrence of assessment indicated by •, collected via phone indicated by •• Phone screening will be completed prior to SV1