Table 3.
Nominally significantly differential association of the AD risk PRS with lipids between AD and controls control.
| Lipid | Beta.PRS | Beta.PRS_CC | SE.PRS | SE.PRS_CC | t.PRS | t.PRS_CC | Pval.PRS | Pval.PRS_CC |
|---|---|---|---|---|---|---|---|---|
| Cer(d18:1_16:0) | 0.197 | −0.511 | 0.133 | 0.195 | 1.483 | −2.624 | 0.142 | 0.011 |
| Cer(t16:1_14:0) | 0.268 | −0.510 | 0.141 | 0.207 | 1.894 | −2.461 | 0.062 | 0.016 |
| ChE(22:5) | −0.080 | 0.539 | 0.137 | 0.200 | −0.583 | 2.690 | 0.562 | 0.009 |
| PC(16:0_20:4) | −0.107 | 0.495 | 0.144 | 0.211 | −0.745 | 2.345 | 0.459 | 0.022 |
| PC(16:0_20:5) | 0.001 | 0.535 | 0.144 | 0.210 | 0.007 | 2.544 | 0.994 | 0.013 |
| PC(16:0_22:6) | 0.150 | 0.419 | 0.123 | 0.180 | 1.221 | 2.331 | 0.226 | 0.022 |
| PC(16:2e_16:0) | 0.089 | −0.428 | 0.145 | 0.212 | 0.612 | −2.018 | 0.543 | 0.047 |
| PC(18:0_20:3) | 0.131 | 0.433 | 0.135 | 0.198 | 0.973 | 2.187 | 0.334 | 0.032 |
| PC(18:1_20:3) | 0.025 | 0.441 | 0.143 | 0.209 | 0.174 | 2.108 | 0.863 | 0.038 |
| PC(18:2_18:2) | −0.005 | 0.415 | 0.138 | 0.202 | −0.039 | 2.053 | 0.969 | 0.044 |
| PC(34:0) | 0.057 | −0.510 | 0.142 | 0.208 | 0.404 | −2.447 | 0.688 | 0.017 |
| PC(37:2) | 0.285 | −0.488 | 0.147 | 0.215 | 1.942 | −2.267 | 0.056 | 0.026 |
| PE(16:0_20:3) | −0.059 | 0.445 | 0.144 | 0.210 | −0.413 | 2.117 | 0.681 | 0.038 |
| PI(18:0_18:2) | 0.026 | −0.421 | 0.123 | 0.180 | 0.208 | −2.346 | 0.836 | 0.022 |
| PI(36:3) | −0.163 | 0.603 | 0.148 | 0.217 | −1.105 | 2.784 | 0.273 | 0.007 |
| SM(d17:1_13:0) | 0.353 | −0.668 | 0.142 | 0.209 | 2.476 | −3.200 | 0.016 | 0.002 |
| SM(d17:1_18:3) | 0.041 | −0.405 | 0.134 | 0.196 | 0.303 | −2.064 | 0.763 | 0.043 |
| SM(d18:2_24:3) | 0.240 | −0.470 | 0.145 | 0.213 | 1.653 | −2.207 | 0.103 | 0.030 |
| SM(d32:4) | 0.166 | −0.585 | 0.134 | 0.197 | 1.233 | −2.971 | 0.222 | 0.004 |
| SM(d33:1) | 0.095 | −0.521 | 0.139 | 0.204 | 0.683 | −2.551 | 0.497 | 0.013 |
| SM(d34:2) | 0.132 | −0.416 | 0.141 | 0.206 | 0.933 | −2.014 | 0.354 | 0.048 |
| SM(d35:1) | 0.204 | −0.462 | 0.148 | 0.216 | 1.384 | −2.134 | 0.171 | 0.036 |
| SM(d36:3) | 0.365 | −0.568 | 0.146 | 0.213 | 2.506 | −2.662 | 0.014 | 0.010 |
| SM(d37:2) | −0.012 | −0.429 | 0.136 | 0.199 | −0.090 | −2.161 | 0.929 | 0.034 |
| SM(d38:1) | 0.006 | −0.419 | 0.127 | 0.186 | 0.049 | −2.250 | 0.961 | 0.027 |
| SM(d38:2) | 0.027 | −0.458 | 0.137 | 0.200 | 0.197 | −2.285 | 0.844 | 0.025 |
| SM(d39:1) | −0.031 | −0.413 | 0.131 | 0.192 | −0.240 | −2.153 | 0.811 | 0.035 |
| SM(d39:2) | 0.108 | −0.516 | 0.139 | 0.203 | 0.776 | −2.539 | 0.440 | 0.013 |
| SM(d40:1) | 0.038 | −0.453 | 0.135 | 0.198 | 0.283 | −2.294 | 0.778 | 0.025 |
| SM(d40:3) | 0.118 | −0.458 | 0.149 | 0.218 | 0.789 | −2.098 | 0.433 | 0.039 |
| SM(d41:4) | −0.070 | −0.397 | 0.135 | 0.198 | −0.520 | −2.003 | 0.605 | 0.049 |
| SM(d42:1) | 0.103 | −0.435 | 0.138 | 0.202 | 0.746 | −2.152 | 0.458 | 0.035 |
| SM(d42:2) | 0.028 | −0.507 | 0.129 | 0.189 | 0.221 | −2.688 | 0.826 | 0.009 |
| SM(d42:3) | 0.041 | −0.494 | 0.140 | 0.205 | 0.296 | −2.409 | 0.768 | 0.018 |
| SM(d43:1) | 0.106 | −0.500 | 0.147 | 0.215 | 0.721 | −2.328 | 0.473 | 0.023 |
| SM(d43:2) | 0.167 | −0.606 | 0.140 | 0.204 | 1.200 | −2.966 | 0.234 | 0.004 |
| SM(d44:4) | 0.019 | −0.421 | 0.136 | 0.200 | 0.143 | −2.107 | 0.887 | 0.038 |
| SM(d44:5) | 0.134 | −0.575 | 0.131 | 0.192 | 1.028 | −3.001 | 0.308 | 0.004 |
| SM(d44:6) | 0.054 | −0.427 | 0.139 | 0.204 | 0.389 | −2.092 | 0.699 | 0.040 |
| SM(t18:0_24:2) | 0.163 | −0.509 | 0.143 | 0.209 | 1.145 | −2.436 | 0.256 | 0.017 |
| SM(t42:1) | 0.240 | −0.578 | 0.139 | 0.204 | 1.724 | −2.832 | 0.089 | 0.006 |
| TG(12:0_17:1_18:2) | −0.122 | 0.473 | 0.144 | 0.211 | −0.848 | 2.243 | 0.399 | 0.028 |
| TG(12:0_18:2_18:2) | −0.159 | 0.555 | 0.134 | 0.196 | −1.191 | 2.832 | 0.237 | 0.006 |
| TG(14:0_14:3_18:2) | −0.136 | 0.470 | 0.143 | 0.209 | −0.950 | 2.250 | 0.345 | 0.027 |
| TG(14:0_18:3_18:3) | −0.046 | 0.518 | 0.135 | 0.197 | −0.345 | 2.623 | 0.731 | 0.011 |
| TG(15:0_14:1_16:1) | −0.048 | 0.463 | 0.129 | 0.189 | −0.375 | 2.453 | 0.709 | 0.017 |
| TG(15:0_16:0_20:5) | −0.063 | 0.480 | 0.133 | 0.195 | −0.474 | 2.464 | 0.637 | 0.016 |
| TG(16:0_14:0_18:3) | −0.142 | 0.468 | 0.138 | 0.202 | −1.032 | 2.317 | 0.305 | 0.023 |
| TG(16:0_14:1_16:1) | −0.198 | 0.579 | 0.146 | 0.213 | −1.360 | 2.711 | 0.178 | 0.008 |
| TG(16:1_12:0_18:2) | −0.046 | 0.421 | 0.142 | 0.208 | −0.324 | 2.023 | 0.747 | 0.047 |
| TG(16:1_20:5_20:5) | 0.088 | 0.503 | 0.126 | 0.185 | 0.696 | 2.724 | 0.488 | 0.008 |
| TG(18:3_14:1_18:2) | −0.045 | 0.412 | 0.141 | 0.206 | −0.319 | 1.999 | 0.751 | 0.049 |
| TG(18:4_14:0_16:1) | −0.155 | 0.616 | 0.143 | 0.209 | −1.082 | 2.944 | 0.283 | 0.004 |
| TG(18:4_16:0_20:4) | −0.081 | 0.525 | 0.141 | 0.207 | −0.571 | 2.533 | 0.570 | 0.013 |
| TG(20:1_20:4_20:4) | 0.304 | −0.531 | 0.144 | 0.210 | 2.117 | −2.524 | 0.038 | 0.014 |
| TG(22:5_18:2_18:2) | −0.078 | 0.454 | 0.147 | 0.215 | −0.529 | 2.110 | 0.598 | 0.038 |
| TG(33:4e) | −0.160 | 0.651 | 0.137 | 0.201 | −1.168 | 3.241 | 0.247 | 0.002 |
Marginal effect: Beta.PRS/SE.PRS/t.PRS/Pval. PRS: Beta coefficient/standard error/t statistics/p value of association between PRS scores and individual lipids.
Interaction effect: Beta.PRS_CC/SE.PRS_CC/t.PRS_CC/Pval.PRS_CC: Beta coefficient/standard error/t statistics/p value of differential association of PRS with lipids between AD and controls control.
Cer ceramides, SM sphingomyelins, ChE cholesteryl esters, DG diglycerides, TG triglycerides, PC phosphatidylcholines, LPC lyso-phosphatidylcholines, PE phosphatidylethanolamines, PI phosphatidylinositols.