Table 4.
Differential interaction of genes with lipids between AD and control.
| Genes | Cer | ChE | DG | PC | PE | PI | SM | TG |
|---|---|---|---|---|---|---|---|---|
| ABCA7 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| BIN1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| CASS4 | ✓ | ✓ | ✓ | ✓ | ||||
| CD2AP | ✓ | ✓ | ✓ | ✓ | ||||
| CD33 | ✓ | ✓ | ✓ | ✓ | ||||
| CELF1 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| CLU | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| CR1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| EPHA1 | ✓ | ✓ | ✓ | |||||
| FERMT2 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| INPP5D | ✓ | ✓ | ✓ | ✓ | ||||
| MEF2C | ✓ | |||||||
| MS4A6A | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| NME8 | ✓ | ✓ | ||||||
| PICALM | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| PTK2B | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| SLC24A4 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| SORL1 | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| ZCWPW1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
“✓”: ≥1 lipid in each lipid class were differentially associated with the named gene between AD and controls.
Cer ceramides, SM sphingomyelins, ChE cholesteryl esters, DG diglycerides, TG triglycerides, PC phosphatidylcholines, LPC lyso-phosphatidylcholines, PE phosphatidylethanolamines, PI phosphatidylinositols.