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. Author manuscript; available in PMC: 2021 Oct 30.
Published in final edited form as: Mol Psychiatry. 2020 Dec 7;26(8):4331–4343. doi: 10.1038/s41380-020-00967-1

Table 2.

Cortical regions with significant volume differences between PTSD and control subjects.

Brain regionsa PTSD Control PTSD vs. Control
N Mean (mm3) SD (mm3) N Mean (mm3) SD (mm3) Diff. (mm3) Effect sizeb FDR P
Frontal regions
 R LOFG 1259 7368.940 1137.590 2079 7562.397 1234.104 −193.456 −0.111 0.000*
 R MOFG 1232 5131.391 819.555 2071 5222.223 844.395 −90.831 −0.067 0.039*
 R IFG-PORB 1269 2696.327 497.214 2092 2764.559 515.613 −68.232 −0.086 0.020*
 R SFG 1211 21834.360 3438.285 2017 22431.852 3589.712 −597.492 −0.082 0.008*
 L LOFG 1265 7565.540 1102.285 2089 7765.323 1162.551 −199.783 −0.107 0.001*
 L MOFG 1250 5160.526 889.396 2082 5288.258 907.856 −127.733 −0.068 0.038*
 L RMFG 1256 15829.645 2737.385 2081 16311.831 2959.738 −482.186 −0.062 0.039*
Insular regions
 R IG 1118 6780.865 1006.828 1880 6847.068 974.675 −66.203 −0.073 0.039*
 L IG 1197 6853.961 1050.529 2014 6962.180 1112.211 −108.219 −0.066 0.036*
Cingulate regions
 L RACC 1258 2684.630 589.660 2090 2758.639 596.734 −74.009 −0.074 0.047*
 L CACC 1266 1848.427 495.657 2090 1939.267 525.090 −90.840 −0.098 0.030*
 L PCC 1270 3242.812 590.116 2095 3341.209 626.234 −98.397 −0.078 0.039*
Temporal regions
 R STG 1209 11434.388 1684.942 2035 11652.213 1787.315 −217.825 −0.081 0.021*
 R MTG 1249 11768.208 1932.620 2074 11941.835 2240.106 −173.627 −0.075 0.020*
 L STG 1207 12107.253 1911.582 1989 12438.862 1913.769 −331.609 −0.089 0.018*
 L STS-banks 1122 2538.936 513.020 1879 2631.318 562.580 −92.382 −0.084 0.039*
Parietal regions
 R precuneus 1258 10119.110 1660.468 2091 10336.908 1758.257 −217.798 −0.065 0.038*
 R SPG 1153 13072.242 2171.277 1974 13293.998 2176.036 −221.756 −0.068 0.039*
 R IPG 1239 15102.197 2586.341 2066 15469.810 2754.932 −367.613 −0.065 0.041*
 L precuneus 1263 9713.105 1606.806 2093 9909.710 1672.397 −196.605 −0.061 0.041*
Occipital regions
 R LING 1186 6786.013 1187.746 1973 6994.104 1187.540 −208.091 −0.110 0.006*
*:

PTSD vs. control difference significant at FDR corrected P < 0.05 level.

a

“L” refers to left hemisphere, and “R” means right hemisphere.

b

The standardized coefficients of linear mixed model were reported for effect sizes.