Table 3.

Significant interaction of age and PTSD diagnosis in cortical volumes.

	All subjects			Age-matched subsamplea
	Age effect			Age effect			PTSD vs. control
Brain regions	Effect sizeb	FDR P	Interaction FDR P	Effect sizeb	FDR P	Interaction FDR P	Effect sizeb	FDR P
Frontal regions
R LOFG	−0.371	3.0 × 10−95*	0.070	−0.302	5.4 × 10−99*	0.918	−0.093	0.012†
R IFG-PORB	−0.388	1.3 × 10−82*	0.096	−0.314	1.8 × 10−80*	0.876	−0.083	0.046†
R SFG	−0.436	1.4 × 10−137*	0.959	−0.350	9.1 × 10−130*	0.930	−0.090	0.012†
L LOFG	−0.413	9.8 × 10−111*	0.121	−0.329	l.O× 10−111*	0.918	−0.085	0.023†
Cingulate regions
L PCC	−0.353	6.1 × 10−62*	0.504	−0.277	2.9 × 10−58*	0.821	−0.088	0.046†
Temporal regions
R STG	−0.342	1.1 × 10−67*	0.305	−0.273	7.2 × 10−68*	0.975	−0.080	0.046†
R MTG	−0.358	1.6 × 10−89*	0.041#	−0.282	2.2 × 10−87*	0.803	−0.080	0.029†
R fusiform	−0.273	2.6 × 10−42*	0.040#	−0.206	1.4 × 10−38*	0.876	−0.064	0.111
R parahippocampal	−0.126	7.1 × 10−15*	0.040#	−0.091	4.3 × 10−13*	0.821	−0.010	0.702
L STG	−0.360	2.8 × l0−71*	0.437	−0.285	7.0 × 10−69*	0.930	−0.084	0.046†
L MTG	−0.355	2.2 × l0−73*	0.040#	−0.281	7.5 × 10−72*	0.821	−0.050	0.179
L ITG	−0.301	4.5 × 10−52*	0.040#	−0.237	1.5 × 10−49*	0.599	−0.059	0.127
Occipital regions
R LING	−0.286	1.0 × 10−39*	0.119	−0.217	1.0 × 10−35*	0.881	−0.118	0.012†

^*:Significant age main effects at FDR corrected p < 0.05 level.

^#:Significant interaction of age and PTSD diagnosis at FDR corrected P < 0.05 level.

^†:Significant PTSD main effect at FDR corrected P < 0.05 level in age-matched subsamples.

^aAnalysis after matching mean ages of PTSD and control groups by excluding the single cohort on older adults, ADNIDOD, and two youngest cohorts, NIRL and FEAR.

^bThe standardized coefficients of linear mixed model were reported for effect sizes.