Table 1.

Time and events table.

Required measures	Screening/ trial entry	Visceral debranching as soon as possible after trial entry	During neoadjuvant chemotherapy intended start date 2 to 3 weeks after debranching	Tumor resection intended date of operation 4–6 weeks after end of chemotherapy	Follow-up 0–36 months after tumor resection
Verification of inclusion and exclusion criteria	♦
Informed consent	♦
CT/MRI	♦			♦ Between end of chemotherapy and resection	♦
Ascertainment of data as detailed in “evaluation and follow-up”	♦	♦	♦	♦
Ascertainment of primary endpoint			♦ Start of neoadjuvant chemotherapy
Follow-up exams at the discretion of the treating physician (including Ca 19-9 measurements and cross-sectional imaging as indicated)					♦
Surgery		♦		♦

Measures to be performed at the time points marked with ♦