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. 2021 May 24;8:675842. doi: 10.3389/fmed.2021.675842

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Copyright © 2021 Zhang, Guo, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical characteristics of differentially expressed circRNAs in cSCC. (A,B) RT-qPCR for validation of the expression of plasma circ-DNA2, circ-SYNE2, circ-CYP24A1, circ-ALDH3A2, circ-LRBA, circ-SENP2, and circ-HLA-B in 5 paired cSCC and healthy individuals. (C-N) The correlations of plasma (C-F) circ-CYP24A1, (G-J) circ-ALDH3A2, and (K-N) circ-DNA2 levels with maximum tumor diameter, tumor thickness, pre-operative serum SCC-Ag and serum SCC-Ag 1 month after surgery. *P-value < 0.05; **p-value < 0.01; ***p-value < 0.001.