Fig. 3.

Mutation distribution. Differences in distribution of mutations across the three main phenotypes: ASD (yellow), Cancer (red) and non-pathogenic (blue) across protein structure (A), and gene (B). Cancer mutations are observed in higher concentrations within the phosphatase region, suggesting a direct effect on PIP₃ dephosphorylation and subsequent tumor suppression. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)