Figure 3.

The role of inflammatory factors in the pathogenesis of ICP. The discovered ones include TNF-α, IL-6, IL-12, IL-17A, IL-31, IL-8, IL-10, and YKL-40, which are represented by red circles. In ICP patients, the number of DCs in the immune cell subgroup CD83+ is higher, while the number of DCs in CD1a+ is lower, indicated by blue circles. In addition, there is the GPBAR1/NF-κB pathway, and UCDA can compete with other bile acids for the GPBAR1 receptor. Regulation events are displayed with arrows.