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. 2021 May 24;12:619069. doi: 10.3389/fimmu.2021.619069

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Copyright © 2021 Wurzer, Filali, Hoffmann, Krecke, Biolato, Mastio, De Wilde, François, Largeot, Berchem, Paggetti, Moussay and Thomas

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The actin response in patient-derived primary CLL cells. (A) Representative confocal microscopy image of an immune synapse between a primary CLL cell (T) and NK-92MI cell (NK). The chart to the right shows the relative fluorescent intensity of SiR-actin along the trajectory (white arrow). The fluorescence was normalized to 1 at the opposite site of the synapse. The region of the immunological synapse is indicated with “IS”. Bar: 10 µm (B) Quantitative imaging flow cytometry analysis of the AR in primary CLL cells in conjugation with NK-92MI effector cells. CLL cells were identified as CD5⁺/CD19⁺ cells. Actin staining was performed using spirochrome labelling. (C) Quantification of primary CLL cells in conjugation with NK-92MI cells after 45 minutes of co-culture as percentage of total target population.