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. 2021 May 1;25:11–24. doi: 10.1016/j.omtn.2021.04.022

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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GAS6-AS1 inhibited progression and glucose metabolism reprogramming of LUAD cells via downregulating GLUT1

(A) Diagram of key enzymes that play vital roles in glucose metabolism reprogramming. (B) The mRNA expression of metabolism-related genes was measured by qRT-PCR after overexpression of GAS6-AS1 in A549 cells. (C) The protein expression of metabolism-related enzymes was measured by western blotting after overexpression of GAS6-AS1 in A549 cells. (D) Ectopic expression of GLUT1 restored the inhibition effect of GAS6-AS1 on proliferation in A549 cells. (E and F) Ectopic expression of GLUT1 restored the inhibition effect of GAS6-AS1 on migration and invasion in A549 cells. (G–J) Glucose consumption (G), lactate production (H), pyruvate production (I), and ECAR (J) were measured, and results indicated that ectopic expression of GLUT1 restored the inhibition effect of GAS6-AS1 on glucose metabolism reprogramming in A549 cells.