Table 1.
Studies evaluating cardiometabolic risk in women with hyperglycemia at 1-h during an OGTT in pregnancy.
| Study | Study design | Number of participants | Geographical location | Key outcomes |
|---|---|---|---|---|
| Buchannan et al. (10) | Longitudinal study | 91 Latino women with GDM | Los Angeles, USA | 1-h PG predictor of diabetes at 1–2 years after pregnancy |
| Lee et al. (13) | Retrospective study | 5,470 women with GDM | Melbourne, Australia | 1-h PG predictor of diabetes at 15 years after pregnancy |
| Wein et al. (14) | Longitudinal study | 2,957 women with GDM | Melbourne, Australia | 1-h PG predictor of diabetes at 6 months after pregnancy |
| Retnakaran et al. (15) | Longitudinal study | 412 pregnant women | Toronto, Canada | 1-h PG predictor of prediabetes/diabetes after 3 months after pregnancy |
| Nishikawa et al. (16) | Retrospective study | 185 women with GDM | Japan | 1-h PG predictor of impaired glucose tolerance after 6–12 weeks after pregnancy |
| Di Cianni et al. (17) | Cross-sectional study | 4,053 pregnant women | Tuscany, Italy | Independent association between 1-h PG and reduced insulin secretion |
| Ghio et al. (18) | Observational cross-sectional study | 4,053 pregnant women | Tuscany, Italy | Progressive increase in 1-h PG levels was associated with both β-cell dysfunction and insulin resistance |
| Leopold et al. (19) | Longitudinal study | 930 pregnant women | Vienna, Austria | Independent association between elevated 1-h PG and cord blood insulin levels and intrapartum hyperinsulinism |
| Retnakaran et al. (20) | Cross-sectional study | 180 pregnant women | Toronto, Canada | Greater independent association between 1-h PG and hyperglycemia and insulin resistance than 2- or 3-h PG |
| Retnakaran et al. (21) | Cross-sectional study | 361 pregnant women | Toronto, Canada | Independent association between 1-h PG and hyperglycemia, insulin resistance and β-cell dysfunction after 3 months post-partum |
| Scholtens et al. HAPO FUS (22) | Longitudinal study | 4,832 children whose mothers were in HAPO study | International, multicentric study | Independent association between maternal glucose levels and higher glucose levels and insulin resistance during childhood |
| Lekva et al. (23) | Prospective cohort study | 300 pregnant women | Oslo, Norway | 1- and 2-h PG predictor of arterial stiffness after 5 years of follow-up |
| Retnakaran et al. (24) | Prospective cohort study | 485 pregnant women | Toronto, Canada | 1h-PG predictor of unfavorable CV profile risk after 3 months post-partum |
| Gungor et al. (25) | Cross-sectional study | 51 pregnant women | Canakkale, Turkey | Direct correlations between 1- and 2-h PG and impaired endothelial function |
| Gobl et al. (26) | Longitudinal study | 110 women with prior GDM | Vienna, Austria | 1-h PG predictor of diabetes after 10 years after pregnancy Association between 1-h PG and subclinical inflammation and adhesion molecules |
| Tumminia et al. (27) | Retrospective study | 297 women with GDM | Catania, Italy | 1-h PG predictor post-partum 1-h OGTT ≥ 155 mg/dl |