FIGURE 7.
Inhibition of Col6a5 attenuates excessive lipid accumulation induced by DHT. DHT acts directly on ovarian and gonad fat cells, leading to lipid metabolism disorder, which in turn leads to excess lipid accumulation and cell hypertrophy. Inhibition of the expression of our screened target gene Col6a5 could alleviate DHT-induced excess lipid accumulation, hypertrophy and abnormal metabolism-related gene expression.