FIGURE 3.

(A) Three-dimensional binding conformations of the synthesized molecules against human serine hydroxymethyltransferase 2 protein (PDB ID: 5V7I). The yellow color dotted lines represent the hydrogen bonds as well as polar interactions. (B) Two-dimensional binding interactions of the docked ligand molecules with target protein. (C) Overlapped structures of the synthesized compounds along with the co-crystalized ligand in the protein active site. (D) The binding energies (kcal/mol) of the docked compounds with target protein.