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Cytotoxicity and structure activity relationship of novel pyran-linked phthalazinone-pyrazole hybrids 4a–h.
| Compound | IC50 (µM ± SD) | |
|---|---|---|
| A549 | HeLa | |
| 4a | 14.1 ± 0.9 | 17.9 ± 1.0 |
| 4b | 10.6 ± 1.2 | 11.8 ± 1.2 |
| 4c | 9.8 ± 0.9 | 10.1 ± 0.9 |
| 4d | 28.9 ± 1.3 | 30.5 ± 1.4 |
| 4e | 26.3 ± 1.2 | 20.9 ± 1.1 |
| 4f | 16.4 ± 1.0 | 18.6 ± 0.9 |
| 4g | 15.6 ± 1.1 | 13.1 ± 0.8 |
| 4h | 41.6 ± 1.8 | 31.6 ± 1.3 |
| Doxorubicin (positive control) | 0.69 ± 0.1 | 0.81 ± 0.1 |
| ||
