Table 2. Large-scaled randomized clinical studies from East Asia comparing LDG and ODG for AGC.

Variables	CLASS-01 (40)	KLASS-02 (15)	JLSSG-0901 (41)
LDG, laparoscopic distal gastrectomy; ODG, open distal gastrectomy; AGC, advanced gastric cancer; DFS, disease-free survival; RFS, relapse-free survival; N/A, not available; *, since phase III results of JLSSG-0901 is yet to be published, results of phase II part is shown here.
Country	China	Korea	Japan
Sample size (n)	1,056	1,050	500
Primary endpoint	3-year DFS	3-year RFS	5-year RFS
Results	LDG, 76.5%; ODG, 77.8%	LDG, 80.3%; ODG, 81.3%	N/A
Noninferiority margin	10%	8%	8%
Study status	Published	Published	Enrollment finished
Pathologic stage* [n (%)]
I	LDG, 151 (29.2); ODG, 152 (29.3)	LDG, 178 (36.2); ODG, 165 (34.2)	LDG, 41 (47.6)
II	LDG, 137 (26.4); ODG, 138 (26.6)	LDG, 148 (30.1); ODG, 167 (34.6)	LDG, 18 (20.9)
III	LDG, 219 (42.3); ODG, 221 (42.6)	LDG, 166 (33.7); ODG, 150 (31.1)	LDG, 27 (31.5)
IV	LDG, 11 (2.1); ODG, 8 (1.5)	N/A	N/A