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. 2021 Apr 30;33(2):243–255. doi: 10.21147/j.issn.1000-9604.2021.02.11

Table 3. Univariate and multivariate analyses of evaluable efficacy PFS patients (N=26).

Characteristics prior enrollment n (%) Univariate analyses Multivariate analyses P Univariate analyses Multivariate analyses P
Median PFS (95% CI) P Median OS (95% CI) P
PFS, progression-free survival; TNBC, triple-negative breast cancer; HR, hormonal receptor; DFS, disease-free survival; IV, primary metastasis; 95% CI, 95% confidence interval; OS, overall survival from enrollment; NE, not evaluable.
Molecular subtype 0.001 0.014 0.120 0.042
 TNBC 8 (30.8) 2.3 (1.2−3.4) 8.0 (0−21.9)
 HR+ 18 (69.2) 7.0 (2.2−11.8) NE
Lymph node metastasis after surgery 0.112 0.081 0.715 0.375
 No 11 (42.3) 6.4 (0.1−18.4) NE
 Yes 11 (42.3) 3.2 (1.0−5.4) 20.0 (5.5−34.5)
 IV 4 (15.4) 5.6 (0.1−14.5) 18.0 (1.9−34.0)
DFS (month) 0.107 0.868 0.022 0.311
 ≤36 15 (57.7) 4.9 (1.9−7.9) 9.0 (7.2−10.8)
 >36 11 (42.3) 8.7 (0.2−20.7) NE
Endocrine therapy prior enrollment 0.323 0.526 0.021 0.918
 No 7 (26.9) 3.2 (2.6−3.7) 7.0 (4.4−9.5)
 Yes 19 (73.1) 6.0 (3.0−8.9) NE
Radiation therapy prior enrollment 0.041 0.057 0.343 0.935
 No 10 (38.5) 6.4 (1.6−19.5) NE
 Yes 12 (46.2) 3.0 (1.3−4.6) 8.0 (0−19.3)
 IV 4 (15.4) 5.6 (0.2−14.5) 18.0 (12.8−23.2)
Site and No. of metastasis 0.258 0.698 0.062 0.031
 1 (Chest wall only) 12 (46.2) 4.9 (0−12.7) NE
 2 (Chest wall and others) 14 (53.8) 4.3 (0−8.7) 8.0 (5.8−10.2)
Line of disease prior enrollment 0.660 0.560 0.720 0.435
 ≤2 13 (50.0) 6.4 (1.9−10.8) 20 (NE)
 >3 13 (50.0) 4.3 (1.1−7.5) 17.0 (4.1−29.9)