TABLE 1.
Relative tissue expression of GRK2, 3, 5, and 6, β-arrestin1 and -2, and ARRDC1-5.
| Index | Tissue | GRK2 | GRK3 | GRK5 | GRK6 | βarr-1 | βarr2 | ARRDC1 | ARRDC2 | ARRDC3 | ARRDC4 | ARRDC5 |
| 1 | Adipose tissue | 13.1 | 28.0 | 15.9 | 6.8 | 20.9 | 21.6 | 8.4 | 26.7 | 40.4 | 9.2 | 0.2 |
| 2 | Adrenal gland | 10.7 | 6.0 | 8.3 | 5.5 | 5.4 | 15.6 | 8.9 | 5.3 | 37.9 | 9.3 | 0.0 |
| 3 | Amygdala | 24.5 | 11.9 | 3.4 | 7.8 | 27.7 | 23.7 | 5.3 | 10.4 | 9.3 | 11.4 | 0.2 |
| 4 | Appendix | 35.8 | 12.4 | 16.8 | 26.8 | 14.7 | 47.8 | 16.9 | 12.5 | 12.3 | 11.5 | 0.7 |
| 5 | B-cells | 4.1 | 6.2 | 9.3 | 9.2 | 0.1 | 2.2 | 9.9 | 5.9 | 4.7 | 0.5 | 2.6 |
| 6 | Basal ganglia | 17.0 | 10.8 | 7.8 | 7.3 | 31.7 | 18.3 | 7.0 | 34.6 | 14.6 | 18.4 | 0.2 |
| 7 | Bone marrow | 78.2 | 7.0 | 2.7 | 68.1 | 9.6 | 102.8 | 22.1 | 39.3 | 68.7 | 6.7 | 2.2 |
| 8 | Breast | 17.0 | 11.3 | 10.2 | 10.2 | 15.9 | 10.0 | 10.7 | 27.7 | 40.8 | 14.8 | 0.2 |
| 9 | Cerebellum | 32.9 | 7.9 | 6.5 | 7.7 | 24.4 | 28.1 | 4.2 | 3.2 | 17.9 | 3.3 | 0.2 |
| 10 | Cerebral cortex | 35.3 | 18.9 | 5.0 | 10.9 | 36.7 | 26.3 | 8.0 | 19.5 | 13.8 | 16.3 | 0.6 |
| 11 | Cervix, uterine | 12.8 | 4.7 | 12.5 | 5.9 | 6.9 | 8.7 | 11.1 | 10.9 | 25.6 | 9.4 | 0.2 |
| 12 | Colon | 17.2 | 4.0 | 18.8 | 9.2 | 17.8 | 16.1 | 21.4 | 9.6 | 18.6 | 27.4 | 0.2 |
| 13 | Corpus callosum | 12.2 | 3.1 | 3.9 | 6.6 | 11.2 | 20.4 | 6.0 | 28.3 | 14.8 | 67.3 | 0.2 |
| 14 | Dendritic cells | 6.0 | 3.7 | 2.2 | 5.7 | 12.7 | 18.0 | 32.1 | 3.1 | 3.4 | 2.4 | 3.9 |
| 15 | Ductus deferens | 12.6 | 0.7 | 4.5 | 5.0 | 2.0 | 1.9 | 23.2 | 7.3 | 9.4 | 11.6 | 0.2 |
| 16 | Duodenum | 17.5 | 3.0 | 12.4 | 10.9 | 15.4 | 23.0 | 24.2 | 6.9 | 4.5 | 11.2 | 0.1 |
| 17 | Endometrium | 11.4 | 5.7 | 13.4 | 8.0 | 7.6 | 7.4 | 6.9 | 7.6 | 30.0 | 10.7 | 0.2 |
| 18 | Epididymis | 9.9 | 3.1 | 12.2 | 6.0 | 4.5 | 7.8 | 12.5 | 4.7 | 14.6 | 11.9 | 0.2 |
| 19 | Esophagus | 20.2 | 2.7 | 8.1 | 11.0 | 13.8 | 7.1 | 22.4 | 8.1 | 28.5 | 11.8 | 0.2 |
| 20 | Fallopian tube | 12.6 | 9.1 | 7.7 | 6.6 | 12.1 | 10.8 | 8.5 | 8.5 | 13.3 | 10.8 | 0.1 |
| 21 | Gallbladder | 17.6 | 5.0 | 19.5 | 9.3 | 9.2 | 14.8 | 20.6 | 13.1 | 17.4 | 14.7 | 0.3 |
| 22 | Granulocytes | 21.0 | 5.6 | 6.5 | 32.1 | 14.7 | 52.9 | 52.7 | 3.7 | 43.1 | 3.1 | 3.3 |
| 23 | Heart muscle | 13.6 | 4.6 | 45.4 | 6.2 | 12.2 | 10.2 | 7.1 | 8.5 | 16.0 | 9.7 | 0.2 |
| 24 | Hippoc. formation | 21.9 | 15.7 | 4.2 | 8.0 | 25.0 | 27.3 | 6.0 | 14.1 | 9.5 | 18.7 | 0.2 |
| 25 | Hypothalamus | 17.4 | 8.3 | 4.2 | 7.3 | 16.0 | 20.9 | 4.8 | 8.2 | 8.6 | 9.2 | 0.1 |
| 26 | Kidney | 13.0 | 3.0 | 4.3 | 5.7 | 9.1 | 10.5 | 13.9 | 10.7 | 23.5 | 14.1 | 0.2 |
| 27 | Liver | 14.1 | 3.4 | 5.7 | 6.6 | 7.4 | 15.6 | 14.6 | 9.8 | 33.4 | 21.8 | 0.2 |
| 28 | Lung | 19.1 | 9.4 | 27.6 | 11.1 | 37.3 | 35.0 | 19.6 | 22.6 | 32.3 | 14.1 | 0.5 |
| 29 | Lymph node | 42.8 | 14.1 | 8.8 | 37.6 | 9.7 | 31.3 | 19.3 | 19.0 | 14.6 | 6.4 | 2.2 |
| 30 | Midbrain | 13.4 | 9.7 | 3.7 | 7.1 | 19.1 | 20.1 | 5.9 | 47.5 | 14.6 | 18.1 | 0.2 |
| 31 | Monocytes | 18.3 | 8.0 | 3.7 | 22.6 | 37.5 | 32.8 | 33.9 | 6.3 | 7.7 | 5.1 | 1.2 |
| 32 | NK-cells | 3.8 | 0.0 | 0.2 | 17.4 | 3.9 | 5.9 | 6.6 | 7.2 | 5.3 | 0.1 | 1.7 |
| 33 | Olfactory region | 19.0 | 9.8 | 2.5 | 10.7 | 25.7 | 19.6 | 7.6 | 9.0 | 5.7 | 15.2 | 0.2 |
| 34 | Ovary | 9.8 | 4.1 | 16.5 | 6.1 | 12.5 | 8.7 | 4.7 | 4.9 | 57.9 | 7.4 | 0.2 |
| 35 | Pancreas | 10.4 | 8.4 | 3.5 | 12.1 | 28.8 | 8.3 | 30.4 | 6.2 | 14.4 | 25.0 | 0.2 |
| 36 | Parathyroid gland | 9.7 | 4.4 | 26.2 | 3.5 | 1.8 | 6.6 | 6.9 | 18.7 | 20.5 | 3.7 | 0.0 |
| 37 | Pituitary gland | 12.2 | 8.2 | 6.3 | 5.6 | 3.3 | 10.2 | 12.0 | 5.7 | 15.4 | 6.5 | 0.2 |
| 38 | Placenta | 12.7 | 4.5 | 24.0 | 4.9 | 17.7 | 16.0 | 15.9 | 8.1 | 44.7 | 13.0 | 0.2 |
| 39 | Pons and medulla | 15.7 | 9.6 | 4.5 | 6.7 | 21.8 | 19.7 | 7.9 | 20.1 | 13.4 | 29.4 | 0.2 |
| 40 | Prostate | 17.8 | 8.2 | 7.5 | 8.1 | 12 | 7.4 | 16 | 10.1 | 26.7 | 8.3 | 0.2 |
| 41 | Rectum | 16.2 | 4.3 | 6.4 | 5.5 | 16.9 | 13.2 | 6.4 | 7.2 | 12.6 | 17 | 0.1 |
| 42 | Retina | 9.3 | 4.8 | 5.6 | 5 | 10.1 | 10.7 | 9.3 | 6 | 17.8 | 4.6 | 0.2 |
| 43 | Salivary gland | 17.4 | 3.7 | 5 | 10.8 | 8.5 | 8.7 | 22.1 | 15.3 | 43.2 | 6.5 | 0.2 |
| 44 | Seminal vesicle | 20.8 | 1.9 | 6.7 | 5.2 | 7.5 | 6.2 | 26.7 | 11.6 | 18.1 | 13.5 | 0.2 |
| 45 | Skeletal muscle | 20.8 | 1.4 | 12.8 | 7.4 | 7.2 | 5.5 | 9.1 | 60.7 | 58.4 | 10.1 | 0.2 |
| 46 | Skin | 23.5 | 4.1 | 4.7 | 7.7 | 11.6 | 5.8 | 15.2 | 9.4 | 24.6 | 25.3 | 0 |
| 47 | Small intestine | 26.3 | 6.1 | 10.4 | 14.5 | 18.5 | 21 | 28.4 | 13.3 | 10.3 | 15.3 | 1 |
| 48 | Smooth muscle | 12.2 | 6.2 | 10.8 | 7.8 | 15.9 | 13.7 | 6.2 | 6.7 | 16.6 | 14 | 0.2 |
| 49 | Spinal cord | 12.5 | 4.9 | 4.8 | 5.4 | 6.4 | 21.7 | 4.7 | 16.8 | 19.9 | 48.7 | 0.3 |
| 50 | Spleen | 59.6 | 23.2 | 17 | 34.3 | 26.5 | 66.6 | 21.5 | 18.7 | 16 | 5.9 | 2.3 |
| 51 | Stomach | 17.4 | 4 | 13.9 | 9.1 | 23.1 | 12.5 | 30.7 | 12.1 | 11.7 | 18.1 | 0.2 |
| 52 | T-cells | 5.3 | 0.4 | 11.3 | 11.7 | 3.6 | 11.4 | 12.4 | 16 | 15.4 | 0.1 | 3.5 |
| 53 | Testis | 6.8 | 14.8 | 3.5 | 10.5 | 3.1 | 5 | 6.9 | 3.2 | 12.7 | 10.2 | 29.1 |
| 54 | Thalamus | 11.1 | 2.7 | 4.7 | 5.1 | 19 | 18.3 | 4.5 | 32.9 | 15.2 | 41.9 | 0.2 |
| 55 | Thymus | 35.9 | 11.6 | 9.8 | 32.3 | 3.8 | 23.5 | 16.6 | 10.5 | 15.6 | 1.9 | 0.2 |
| 56 | Thyroid gland | 10.1 | 4.5 | 8.9 | 5.3 | 6.4 | 6.4 | 14.4 | 14.3 | 59 | 14.9 | 0.2 |
| 57 | Tongue | 13.6 | 1.3 | 10.7 | 6.4 | 3.9 | 3.2 | 11.6 | 4.9 | 17.2 | 4.5 | 0.2 |
| 58 | Tonsil | 37.5 | 15.2 | 8.6 | 26.5 | 7.2 | 17 | 21.2 | 19.1 | 24.1 | 3.5 | 0.8 |
| 59 | Total PBMC | 7.4 | 1.6 | 4.2 | 9.1 | 10.9 | 16 | 13.4 | 4.7 | 6.4 | 0.8 | 0.9 |
| 60 | Urinary bladder | 17.1 | 6.7 | 9.5 | 11.4 | 13.2 | 15.7 | 11.4 | 9.3 | 47.7 | 11.7 | 0.2 |
| 61 | Vagina | 15.5 | 2.5 | 13.6 | 6.5 | 7.9 | 7.1 | 12.6 | 11.3 | 26 | 12.4 | 0.2 |
Consensus transcriptomics data of the Human Protein Atlas, the Genotype-Tissue Expression, and the Functional Annotation of Mammalian Genomes 5 project as normalized expression (NX) calculated in relation to the maximum NX value in the three sources for each gene. The data are based on the Human Protein Atlas version 20.1 (https://www.proteinatlas.org/), last accessed March 10th, 2021.