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. 2021 Jun 3;17:17448069211021698. doi: 10.1177/17448069211021698

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — No significant effect of NB001 on acute pain. (a) Effect of NB001 in hot plate test at 55 °C. There was no significant difference in response latency before and after oral injection of saline and NB001 (10 mg/kg) (n = 8) in hot plate test set at 55 °C. (b) Effect of NB001 in tail-flick (TF) test. Oral injection of NB001 (10 mg/kg) did not affect spinal nociceptive TF reflex (n = 8). (c) Comparison of behavioral responses to non-noxious mechanical stimulus. There was no significant difference in hindpaw withdrawal to von Frey filaments before and after oral injection of saline and 10 mg/kg NB001 in normal mice (n = 8).