Fig. 3.

Principal component analysis of the five automated T2-FLAIR processing measures (A-D). Two components explained most of the overall variance in the T2-FLAIR measures (A). The first component was comprised largely of measures relating to white matter damage and thalamus volume (B). The second component was comprised largely of measures relating to central nervous system atrophy (C). Subjects with progressive MS exhibited a wider degree of variability across the second component (D). Abbreviations: T2-FLAIR, T2-weighted fluid attenuated inversion recovery; Dim, dimension; SCLV, salient central lesion volume; LVV, lateral ventricular volume; MOV, medulla oblongata volume; RRMS, relapsing-remitting MS; PMS, progressive MS; CIS, clinically isolated syndrome.