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. 2021 May 24;31:102705. doi: 10.1016/j.nicl.2021.102705

Table 2.

Predicting variance in standard research-quality MRI measures using all five T2-FLAIR MRI measures (β) and each individually (r). All β values reported are standardized and R2 values are adjusted for the number of factors in each model. Abbreviations: T2-FLAIR, T2-weighted fluid attenuated inversion recovery; LVV, lateral ventricular volume; MOV, medulla oblongata volume; T2LV, T2-weighted lesion volume; SCLV, salient central lesion volume; T1LV, T1-weighted hypointense lesion volume; CGMV, neocortical gray matter volume; WM, white matter.

Combined Model
 Independent Correlations
β p r P
Brain Volume LVV −0.372 <0.001 −0.601 <0.001
Combined Model
R2 = 0.546
p < 0.001 		Thalamus Volume 0.325 <0.001 0.659 <0.001
MOV 0.111 0.104 0.315 <0.001
SCLV −0.215 0.011 −0.557 <0.001
Network Efficiency 0.081 0.343 −0.483 <0.001
Thalamus Volume LVV −0.019 0.513 −0.457 <0.001
Combined Model
R2 = 0.902
p < 0.001 		Thalamus Volume 0.827 <0.001 0.946 <0.001
MOV 0.141 <0.001 0.419 <0.001
SCLV 0.059 0.121 −0.574 <0.001
Network Efficiency −0.099 0.012 −0.419 <0.001
MOV LVV 0.043 0.529 0.005 0.938
Combined Model
R2 = 0.476
p < 0.001 		Thalamus Volume −0.020 0.835 0.353 <0.001
MOV 0.722 <0.001 0.678 <0.001
SCLV −0.018 0.841 −0.144 0.059
Network Efficiency 0.071 0.440 −0.060 0.433
T2LV LVV 0.017 0.296 0.457 <0.001
Combined Model
R2 = 0.970
p < 0.001 		Thalamus Volume −0.001 0.982 −0.623 <0.001
MOV −0.001 0.939 −0.269 <0.001
SCLV 0.893 <0.001 0.982 <0.001
Network Efficiency 0.107 <0.001 0.796 <0.001
Network Efficiency * LVV 0.009 0.918 0.427 <0.001
Combined Model
R2 = 0.550
p < 0.001 		Thalamus Volume −0.449 <0.001 −0.708 <0.001
MOV −0.007 0.941 −0.367 <0.001
SCLV 0.013 0.908 0.624 <0.001
Network Efficiency 0.333 0.001 0.684 <0.001
T1LV LVV −0.097 0.142 0.287 0.001
Combined Model
R2 = 0.506
p < 0.001 		Thalamus Volume −0.121 0.197 −0.485 <0.001
MOV 0.033 0.642 −0.137 0.071
SCLV 0.090 0.305 0.586 <0.001
Network Efficiency 0.634 <0.001 0.714 <0.001
CGMV LVV 0.156 0.011 −0.202 0.008
Combined Model
R2 = 0.565
p < 0.001 		Thalamus Volume 0.739 <0.001 0.727 <0.001
MOV 0.147 0.027 0.334 <0.001
SCLV 0.085 0.291 −0.371 <0.001
Network Efficiency −0.046 0.570 −0.379 <0.001

*DWI data were only available for 98 study participants.