Table 4.

Predicting disability progression (DP) over 5 years from the baseline T2-FLAIR processing measures and standard research-quality MRI measures. Abbreviations: %CC, Percent correctly classified; RRMS, relapsing-remitting multiple sclerosis; PMS, progressive multiple sclerosis; CIS, clinically isolated syndrome; T2-FLAIR, T2-weighted fluid attenuated inversion recovery; DP, disability progression; RRMS, relapsing-remitting MS; PMS, progressive MS; CIS, clinically isolated syndrome.

		All (n = 166)		RRMS (n = 99)		PMS (n = 47)		CIS (n = 20)
		%DP = 33.7		%DP = 32.0		%DP = 40.8		%DP = 27.3
		β	p	β	p	β	p	Β	p
T2-FLAIR Model	LVV	−0.052	0.561	−0.001	0.993	−0.132	0.491	–	–
All: %CC = 66.9, R2 = 0.085, p = 0.072 RRMS: %CC = 69.8, R2 = 0.145, p = 0.034 PMS: %CC = 65.9, R2 = 0.101, p = 0.531 CIS: %CC = NA, R2 = NA, p = NA	Thalamus Volume	0.039	0.752	−0.048	0.760	0.436	0.087	–	–
	MOV	−0.044	0.657	−0.080	0.517	−0.177	0.405	–	–
	SCLV	−0.196	0.095	−0.181	0.230	−0.151	0.504	–	–
	Network Efficiency	−0.068	0.584	−0.122	0.411	−0.293	0.460	–	–
Standard Research-Quality MRI Model*	BPV	0.230	0.206	0.202	0.341	0.215	0.628	–	–
All: %CC = 69.7, R2 = 0.100, p = 0.098 RRMS: %CC = 72.4, R2 = 0.196, p = 0.022 PMS: %CC = 71.1, R2 = 0.075, p = 0.864 CIS: %CC = NA, R2 = NA, p = NA	Thalamus Volume	0.109	0.515	0.002	0.992	0.293	0.360	–	–
	MOV	0.061	0.485	0.061	0.567	0.085	0.643	–	–
	T2LV	0.209	0.052	0.235	0.066	0.119	0.632	–	–
	T1LV	0.033	0.727	0.104	0.402	0.046	0.816	–	–
	NCV	0.092	0.494	0.273	0.084	0.253	0.535	–	–

*DWI data were only available for 98 study participants and therefore network efficiency was not used in this model.