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. 2021 May 5;21:356–366. doi: 10.1016/j.omto.2021.04.016

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© 2021 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Humoral response against GD2 and viruses induced by GD2m-expressing OVs

The serum was collected from NXS2-bearing mice treated with PBS, VVs (VV-dTK or VV-GD2m), or SFVs (SFV or SFV-GD2m) for antibody measurement. (A and B) Anti-GD2 antibody level is shown as absorbance determined by ELISA (mean ± SEM). One-way ANOVA with Bonferroni correction was used to compare the mean values between each group (∗∗∗∗p < 0.0001). (C and D) Virus-specific neutralizing antibody measured in the serum. VV-GD2m or SFV-GFP virus was incubated with serially diluted serum as indicated and applied on 911 cells. Renilla luciferase activity (VV) or percentage of GFP-positive cells (SFV) was quantified. Normalized neutralizing response was presented and shown as mean ± SEM. Groups were compared using one-way ANOVA with Bonferroni correction.