Fig. 6.

R51Q SNX10 abolishes a regulatory mechanism that blocks fusion between pairs of mature OCLs. (A) During osteoclastogenesis in vitro, round mature OCLs become surrounded by similarly mature OCLs, with which they form high-MPC interactions. In +/+ cultures (left), fusion halts at this point, but in RQ/RQ cultures (right) this is followed by massive continuous fusion. Gray dots indicate nuclei, and dashed lines represent SZLs. (B) Pairs of mature round OCLs of high-MPC values do not fuse in +/+ cultures, but fuse readily in RQ/RQ cultures. (C) OCL pairs of low-MPC values fuse in both genotypes.