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. 2021 Apr 21;38(9):1292–1305. doi: 10.1089/neu.2020.7324

FIG. 1.

FIG. 1.

C2 Hemi-section model and intermittent hypoxia protocols. (A) Schema depicting C2 spinal cord hemi-section injury model. Briefly, the left side of the spinal cord was cut at C2, severing descending projections to ipsilateral phrenic motoneurons, paralyzing the ipsilateral hemidiaphragm. (B) Schema depicting 28 days of normoxia (Nx28), daily acute intermittent hypoxia (dAIH28), and intermittent hypoxia simulating moderate sleep apnea (IH28-2/2) pre-conditioning protocols. Pre-conditioning was conducted daily for 4 weeks, beginning 8 weeks post-injury (or the equivalent timepoint in intact rats). Nx28 consisted of 8 h of continuous normoxia (21% O2) per day. dAIH consisted of ten 5-min episodes of 10.5% O2, with 5-min normoxic intervals. IH28-2/2 consisted of 8 h of 2-min hypoxic episodes (10.5% O2), with 2-min normoxic intervals.