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. 2021 Apr 21;38(9):1292–1305. doi: 10.1089/neu.2020.7324

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Copyright 2021, Mary Ann Liebert, Inc., publishers

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FIG. 6. — Phrenic long-term facilitation (pLTF) following moderate acute intermittent hypoxia (mAIH). (A) Representative traces depict integrated ipsilateral (left) phrenic neurograms at baseline (black) overlaid on neurogram traces 90 min post-hypoxia (red). (B) Average ipsilateral pLTF (% increase from baseline) was enhanced in rats with chronic C2 hemisection (C2Hx) exposed to daily acute intermittent hypoxia (dAIH28) vs. intact rats. In C2Hx rats exposed to intermittent hypoxia simulating moderate sleep apnea (IH28-2/2), pLTF was not different from intact 28 days of normoxia (Nx28) rats; an apparent difference from dAIH28 rats did not reach statistical significance (p = 0.168). (C) Representative traces depict integrated contralateral (right) phrenic neurograms at baseline (gray) vs. 90 min post-mAIH (black). (D) Average contralateral pLTF was enhanced in dAIH-treated rats with chronic C2Hx. Although C2Hx rats exposed to IH28-2/2 tended to have blunted pLTF (vs. dAIH-treated), this difference did not reach statistical significance (p = 0.1). *Significantly different from intact Nx28; p < 0.05. #Significantly different from C2Hx Nx28; p < 0.05.