Table 6.
PAO2, PACO2, and pH at Baseline, H1, H2, H3 and 90 Min after Moderate Acute Intermittent Hypoxia
| Intact Nx28 | C2Hx Nx28 | C2Hx dAIH28 | C2Hx IH28-2/2 | |
|---|---|---|---|---|
| PAO2 | ||||
| Baseline | 345.2 ± 5.1 | 344.6 ± 4.9 | 343.2 ± 4.4 | 334.1 ± 5.4 |
| H1*# | 43.8 ± 2.1 | 46.2 ± 2.1 | 44.3 ± 1.7 | 47.9 ± 1.3 |
| H2*# | 43.1 ± 0.8 | 44.3 ± 0.9 | 43.1 ± 1.1 | 43.9 ± 1.2 |
| H3*# | 43.3 ± 0.6 | 43.7 ± 0.5 | 42.4 ± 0.7 | 43.1 ± 0.7 |
| 90 min* | 335.9 ± 3.2 | 335.6 ± 7.1 | 322.8 ± 7.6 | 315.1 ± 8.8 |
| PACO2 | ||||
| Baseline | 44.5 ± 1.1 | 41.9 ± 0.6 | 44.5 ± 1.0 | 43.9 ± 0.7 |
| H1 | 45.7 ± 1.3 | 42.4 ± 0.7 | 45.0 ± 1.1 | 44.1 ± 0.9 |
| H2 | 44.8 ± 1.4 | 42.6 ± 0.9 | 44.6 ± 0.9 | 44.2 ± 0.8 |
| H3 | 45.5 ± 1.1 | 41.5 ± 0.9 | 45.2 ± 1.3 | 44.3 ± 0.8 |
| 90 min | 45.6 ± 1.1 | 42.8 ± 0.8 | 44.9 ± 1.0 | 44.1 ± 0.7 |
| pH | ||||
| Baseline | 7.38 ± 0.01 | 7.40 ± 0.01 | 7.39 ± 0.00 | 7.39 ± 0.00 |
| H1# | 7.37 ± 0.01 | 7.40 ± 0.01 | 7.38 ± 0.00 | 7.38 ± 0.00 |
| H2*# | 7.37 ± 0.01 | 7.40 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.00 |
| H3# | 7.36 ± 0.01 | 7.40 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.00 |
| 90 min* | 7.35 ± 0.01 | 7.36 ± 0.01 | 7.36 ± 0.01 | 7.37 ± 0.01 |
*
Different from baseline.
#
Different from 90 min.
Nx28, 28 days of normoxia; C2Hx, chronic C2 hemisection; dAIH, daily acute intermittent hypoxia; IH28-2/2, intermittent hypoxia simulating moderate sleep apnea; H, hypoxic episode.