Table 3. Association between the ERCC1/2 gene polymorphisms and prognosis in 87 NSCLC patients who received definitive radiotherapy.
Gene | MST (months) | 95% CI | P | Median PFS (months) | 95% CI | P |
---|---|---|---|---|---|---|
rs11615 | ||||||
AA | 6.77 | 0–14.05 | 0.000 | 5.13 | 0–15.13 | 0.019 |
AG | 19.77 | 11.14–28.40 | 11.33 | 5.76–16.91 | ||
GG | 30.90 | 12.83–48.97 | 18.87 | 12.56–19.58 | ||
A allele | 16.17 | 9.10–23.24 | 0.024 | 11.33 | 8.66–14.01 | 0.005 |
G allele | 30.90 | 12.83–48.97 | 18.87 | 13.96–23.78 | ||
rs3212961 | ||||||
GG | 24.77 | 4.75–44.79 | 0.735 | 11.53 | 6.41–16.66 | 0.910 |
GT | 23.97 | 15.75–32.19 | 18.07 | 12.67–23.47 | ||
TT | 24.93 | 9.37–40.49 | 11.60 | 5.28–19.92 | ||
G allele | 24.93 | 18.95–30.91 | 0.441 | 16.17 | 11.84–20.50 | 0.897 |
T allele | 24.77 | 4.75–44.79 | 11.53 | 6.41–16.66 | ||
rs3212986 | ||||||
AA | 71.13 | 0–160.416 | 0.092 | 15.53 | 0–38.01 | 0.718 |
AC | 29.10 | 18.92–39.28 | 18.70 | 11.91–25.49 | ||
CC | 21.53 | 12.97–30.09 | 14.67 | 8.849–20.49 | ||
A allele | 30.90 | 15.68–46.12 | 0.086 | 18.01 | 8.85–20.49 | 0.423 |
C allele | 21.53 | 12.97–30.09 | 14.67 | 11.89–24.25 | ||
rs13181 | ||||||
TT | 24.93 | 12.67–36.87 | 0.692 | 19.07 | 9.96–28.19 | 0.921 |
TG | 24.77 | 16.19–33.67 | 16.47 | 10.17–19.17 | ||
rs238406 | ||||||
TT | 16.17 | 0–36.26 | 0686 | 11.33 | 8.92–13.74 | 0.143 |
TG | 28.67 | 22.72–34.62 | 21.50 | 16.86–26.14 | ||
GG | 19.80 | 13.76–25.84 | 11.30 | 6.67–15.93 | ||
T allele | 26.83 | 21.44–32.22 | 0.562 | 16.83 | 12.16–21.50 | 0.097 |
G allele | 19.80 | 13.76–25.84 | 11.30 | 6.67–15.93 | ||
rs1799793 | ||||||
CC | 25.40 | 18.74–32.05 | 0.222 | 15.53 | 11.79–19.27 | 0.411 |
CT | 19.07 | 10.48–27.66 | 16.13 | 2.89–29.37 |
NSCLC, non-small cell lung cancer; CI, confidence interval; MST, median overall survival time; PFS, progression-free survival.