Table 1.
Characteristic | 1 mg/kg Q3W | 3 mg/kg Q3W | 10 mg/kg Q3W | 200 mg Q3W | All patients |
---|---|---|---|---|---|
Number of patients | 6 | 8 | 6 | 10 | 30 |
Age, years | |||||
Median | 64.5 | 49.5 | 47.5 | 55.5 | 54 |
Range | 35–72 | 24–66 | 36–61 | 27–68 | 24–72 |
Sex | |||||
Male | 1 (16.7) | 7 (87.5) | 3 (50.0) | 6 (60.0) | 17 (56.7) |
Female | 5 (83.3) | 1 (12.5) | 3 (50.0) | 4 (40.0) | 13 (43.3) |
ECOG performance status | |||||
0 | 0 | 0 | 0 | 0 | 0 |
1 | 6 (100.0) | 8 (100.0) | 6 (100.0) | 10 (100.0) | 30 (100.0) |
Prior surgery, n (%) | 4 (66.7) | 8 (100.0) | 5 (83.3) | 7 (70.0) | 24 (80.0) |
Tumor type, n (%) | |||||
Colorectal cancer | 1 (16.6) | 1 (12.5) | 2 (33.3) | 2 (20.0) | 6 (20.0) |
Breast cancer | 3 (50.0) | 0 | 1 (16.6) | 2 (20.0) | 6 (20.0) |
Esophageal cancer | 1 (16.6) | 2 (25.0) | 0 | 0 | 3 (10.0) |
Pancreatic cancer | 0 | 0 | 0 | 2 (20.0) | 2 (6.7) |
Soft tissue sarcoma | 0 | 2 (25.0) | 0 | 0 | 2 (6.7) |
Neuroendocrine tumor | 0 | 0 | 1 (16.6) | 1 (10.0) | 2 (6.7) |
Lung cancer | 0 | 0 | 2 (33.3) | 0 | 2 (6.7) |
Gastric cancer | 1 (16.6) | 0 | 0 | 0 | 1 (3.3) |
Cecum cancer | 0 | 0 | 0 | 1 (10.0) | 1 (3.3) |
Thymic cancer | 0 | 0 | 1 (16.6) | 0 | 1 (3.3) |
Kidney cancer | 0 | 1 (12.5) | 0 | 0 | 1 (3.3) |
Ovarian cancer | 0 | 0 | 1 (16.6) | 0 | 1 (3.3) |
Cholangiocarcinoma | 0 | 1 (12.5) | 0 | 0 | 1 (3.3) |
Melanoma | 0 | 1 (12.5) | 0 | 0 | 1 (3.3) |
ECOG,; Eastern Cooperative Oncology Group; FAS, full analysis set; n, number of patients; Q3W, every 3 weeks.