Table 4.
Pharmacokinetic parameters for pucotenlimab.
| 1 mg/kg (n = 6) | 3 mg/kg (n = 8) | 10 mg/kg (n = 6) | 200 mg (n = 10) | |
|---|---|---|---|---|
| Cycle 1 | ||||
| AUC0-t (h*µg/ml) | 3146.93 (483.72) | 11303.14 (4151.55) | 33912.21 (3867.77) | 11792.82 (2447.67) |
| Cmax (µg/ml) | 14.49 (3.00) | 59.49 (17.48) | 169.77 (24.30) | 58.41 (11.72) |
| Tmax (h) | 2.97 (1.03,8.52) | 2.86 (0.98,2.97) | 2.94 (0.98, 9.18) | 2.88 (1.02, 8.83) |
| T1/2 (h) | 553.81 (376.79) | 411.52 (228.83) | 564.21 (129.22) | 522.30 (335.11) |
| Cycle 6 | ||||
| AUC0-t (h*µg/ml) | 8142.02 (3823.98) | 24307.45 (4527.51) | 87646.46 (29017.73) | 31700.03 (4960.76) |
| Cmax (µg/ml) | 27.74 (10.37) | 82.04 (13.20) | 345.72 (84.76) | 102.22 (20.50) |
| Tmax (h) | 2.95 (2.95,3.05) | 3.10 (2.87,3.13) | 2.82 (2.80,8.75) | 2.87 (2.85, 9.12) |
| T1/2 (h) | 441.77 (111.90) | 865.48 (445.15) | 518.86 (112.35) | 915.94 (541.89) |
*
Mean values (SD) provided, except for Tmax, which is reported as medians (range).
AUC0-t, area under the curve from zero up to a definite time t; Cmax, maximum serum concentration; SD, standard deviation; T1/2, half-life; Tmax, time at Cmax