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. 2021 May 18;17:1181–1312. doi: 10.3762/bjoc.17.90

Scheme 32.

Scheme 32

Continuous solvent-free apparatus applied for the synthesis of compounds 140143 using a TSE. Throughput rate and space time yields (in brackets) are reported. aThe data are from the multicomponent reaction process instead of the Knoevenagel–Michael addition telescoped one.