Table 4.

Flow approach advantage and disadvantages.

Advantages	Disadvantages
• increased levels of automation	• quenching/work-up issues
• high heat (surface-to-volume ratio) and mass transfer rates	• dilution effects of additional downstream flow streams
• potential for in-line purification and telescoping	• solvent limitations for multistep procedures
• compatibility with “forbidden chemistries”	• inability to compensate for reaction kinetics
• efficient mixing	• start-up and shut-down procedures
• linear scalability and high throughput	• issues with heterogeneity
• health and safety implications	• higher training and implementation requirements
• facile access to high temperatures and pressures