Table 3. Multivariable Cox proportional hazards regressions for patients with stage I invasive adenocarcinoma who underwent complete resection and lymph node dissection.
| Variables | RFS | OS | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Sex | |||||||
| Male | (Ref =1) | (Ref =1) | |||||
| Female | – | – | 0.067 | – | – | 0.349 | |
| Smoking history | |||||||
| No | (Ref =1) | (Ref =1) | |||||
| Yes | – | – | 0.187 | 1.990 | 1.284–3.083 | 0.002 | |
| Adjuvant chemotherapy | |||||||
| No | (Ref =1) | (Ref =1) | |||||
| Yes | – | – | 0.059 | – | – | 0.294 | |
| Proposed new pathology | |||||||
| nLEP | (Ref =1) | <0.001 | (Ref =1) | ||||
| nACN | 2.948 | 0.700–12.422 | 0.141 | – | – | 0.548 | |
| nPAP | 2.376 | 0.573–9.855 | 0.233 | – | – | 0.780 | |
| nSOL | 5.428 | 1.277–23.074 | 0.022 | – | – | 0.085 | |
| nMIP | 10.784 | 2.415–48.154 | 0.002 | – | – | 0.176 | |
| Others | 2.856 | 0.517–15.784 | 0.229 | – | – | 0.394 | |
| 8th TNM Classification | |||||||
| IA1 | (Ref=1) | <0.001 | (Ref=1) | ||||
| IA2 | 2.081 | 0.736–5.885 | 0.167 | 2.609 | 0.611–11.136 | 0.195 | |
| IA3 | 3.231 | 1.144–9.127 | 0.027 | 4.125 | 0.974–17.475 | 0.054 | |
| IB | 4.202 | 1.504–11.736 | 0.006 | 5.176 | 1.243–21.557 | 0.024 | |
| LVI | |||||||
| No | (Ref=1) | – | – | – | |||
| Yes | – | – | 0.168 | – | – | – | |
RFS, recurrence-free survival; OS, overall survival; Ref, reference; HR, hazard ratio; CI, confidence interval; nLEP, new classification of LEP; nACN, new classification of ACN; nPAP, new classification of PAP; nSOL, new classification of SOL; nMIP, new classification of MIP; TNM, tumor, node, metastasis; PI, pleural invasion; LVI, lymphovascular invasion.