Fig. 6. In vivo biodistribution and penetration study.
a Mean plasma drug concentration-time in rats. b Fluorescence images and c biodistribution of different formulations in major organs, including the heart, liver, spleen, lung and kidney, and tumors of mice 24 h after intravenous injection of L-PMSN-PTX/ATO, PL-PMSN-PTX/ATO, and FPL-PMSN-PTX/ATO. Scale bar = 0.5 cm. d Fluorescence distribution and e in vivo penetration at the tumor site at 24 h after administration of L-PMSN-PTX/ATO, PL-PMSN-PTX/ATO, and FPL-PMSN-PTX/ATO.