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. 2021 Apr 6;42(5):832–842. doi: 10.1038/s41401-021-00648-x

Fig. 6. In vivo biodistribution and penetration study.

Fig. 6

a Mean plasma drug concentration-time in rats. b Fluorescence images and c biodistribution of different formulations in major organs, including the heart, liver, spleen, lung and kidney, and tumors of mice 24 h after intravenous injection of L-PMSN-PTX/ATO, PL-PMSN-PTX/ATO, and FPL-PMSN-PTX/ATO. Scale bar = 0.5 cm. d Fluorescence distribution and e in vivo penetration at the tumor site at 24 h after administration of L-PMSN-PTX/ATO, PL-PMSN-PTX/ATO, and FPL-PMSN-PTX/ATO.