Table 1.

Included studies characteristics

Studies, year	Studies characteristics
	Location	Design	Sample size	Population/Sample	Index Test	Index Test Gene Target	Reference Test	Ref. Test Gene Target	Clinical settings
16	Calgary, Canada	Cross- sectional	124	COVID-19 patients/Archived nasopharyngeal swab	Warmstart RT-LAMP assay	S and RdRP gene	RT-PCR	E gene and N2 gene	N/A
13	Penzberg, Germany	Cross-sectional	137	COVID-19 patients/Archived nasopharyngeal swab	Variplex RT-LAMP assay	[M] gene	LightMix E-Gene RT-PCR*	E gene	N/A
8	Hongkong	Cross-sectional	362	COVID-19 and other viral infection/Nasopharyngeal swab	COVID-19 RT-LAMP assay	orf3a and E gene	qRT-PCR	N/A	Inpatient
14	Saitama, Japan	Cross-sectional	76	Suspected COVID-19 patient/N/A	Loopamp SARS-COV-2 Detection Kit	N/A	qRT-PCR	N gene	Outpatient
1	Guangdong, China	Cohort	481	Suspected COVID-19 patient/N/A	RT-LAMP Kit	S gene	ABI COVID-19 qRT-PCR Kit*	ORF1ab geneN genes	Inpatient
18	Wenzhou, China	Cross-sectional	260	COVID-19 and other viral infection/Nasopharyngeal swab	RT-LAMP Kit	N gene	NPMA qRT-PCR	orf1ab gene, N gene	N/A
6	Beijing, China	Cross-sectional	130	COVID-19 and pneumonia patients/|Nasopharyngeal swab	Loopamp RNA amplification kit [RT-LAMP]	orf1ab gene; S gene	BGI RT-PCR Kit*	orf1ab and S genes	N/A
4	Belmont, USA	Cross-sectional	20	N/A/Serum, urine, oropharyngeal,nasopharyngeal swab	RT-LAMP Kit	NSP 3 gene; ORF1Ab gene	qRT-PCR	N1 and N2 gene	Outpatient
5	Nantong, China	Cross-sectional	56	Suspected COVID-19 patients/Nasopharyngeal swab	Warmstart RT-LAMP Assay	N gene	RT-qPCR kit	N/A	Inpatient
7	Seoul, South Korea	Cross-sectional	154	COVID-19 and other viral infection/Nasopharyngeal swab	Warmstart RT-LAMP Assay	N gene	Bio-rad iTaq Universal Probes One-Step Kit qRT-PCR***	N/A	N/A
17	Melbourne, Australia	Cross-sectional	157	N/A/Nasopharyngeal swabs	RT-LAMP Mastermix	N gene	Quantabio qScript XLT One-Step RT-qPCR ToughMix**	E gene	N/A
12	Heidelberg, Germany	Cross-sectional	77	Random eligible sample/Nasopharyngeal swab	Colorimetric and Fluorescence RT-LAMP	N gene	LightCycler® Multiplex RNAVirus Master kit***	E gene	N/A
15	Sungai Buloh, Malaysia	Cross-sectional	89	COVID-19 patients/Archived nasopharyngeal swab	RT-LAMP Kit	RdRP and E genes	Invitrogen Superscript III one step RT-PCR system*	RdRP and E genes	N/A
9	Ningbo, China	Cross-sectional	16	COVID-19 and other viral infection/Nasopharyngeal swab	RT-LAMP Kit	orf1ab, N, and E gene	Shanghai ZJ Bio- Tech 2019-nCoV RT-PCR kit*	orf1ab, S, and N gene	Outpatient

Legend: E (envelope]; N (nucleocapsid), S (spike protein); M (membrane protein); ORF1ab (Open Reading Frame 1ab); RdRP (RNA dependent RNA polymerase gene); NSP3 (nonstructural protein 3)

Notes:

*Approved reference method by WHO

**Approved reference method by CDC*** Approved reference method by FDA