Table 1.
Patient demographics, number of eyes observed and visual acuity outcomes.
| Baseline | 12 months | 24 months | 36 months | 48 months | |
|---|---|---|---|---|---|
| Patients | 1964 | 1409 | 1137 | 800 | 479 |
| Gender (% female:male) | (40:60) | (41:59) | (41:59) | (40:60) | (42:58) |
| Age (mean ± SD) | 63 ± 12 | 64 ± 12 | 65 ± 12 | 66 ± 11 | 67 ± 11 |
| Eyes | 2614 | 1904 | 1533 | 1051 | 620 |
| Injections per eye (mean ± SD) | – | 6.4 ± 2.4 | 8.9 ± 4.3 | 11.1 ± 6.0 | 14.0 ± 8.0 |
| Deaths (%) | 0 | 1 (0.0005%) | 45 (0.02%) | 92 (0.05%) | 102 (0.05%) |
| Eyes seen in clinic | 2614 | 1904 | 1533 | 1051 | 620 |
| Receiving treatments | 2614 | 1345 | 841 | 509 | 256 |
| Observation only | 0 | 559 | 692 | 542 | 364 |
| Eyes not seen in clinic (%) | 0 | 710 (27%) | 1081 (41%) | 1563 (60%) | 1994 (76%) |
| Datapoint not available | 0 | 86 | 29 | 15 | 2 |
| Treatment duration less than time point | 0 | 624 | 1052 | 1548 | 1992 |
| Mean visual acuity (ETDRS letters ± SD) | 61.0 ± 15.3 | 66.2 ± 15.5 | 65.8 ± 15.8 | 64.1 ± 17.0 | 61.8 ± 18.2 |
| Mean change in visual acuity (ETDRS letters) | – | 5.2 ± 12.8 | 4.8 ± 13.5 | 3.4 ± 15.7 | 2.5 ± 17.3 |
Eyes were classified to ongoing treatment, observation only, datapoint not available and treatment duration less than time point.