Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Melatonin alleviates Ti-particles induced osteolysis through the enrichment of gut microbiota metabolite butyrate. Melatonin reverses the dysbacteriosis triggered by inflammatory osteolysis and raises the relative abundance of SCFA producing bacterium. Enrichment of butyrate following the change of microbiota activates GPR109A and suppresses osteolysis via inhibiting NLRP3 inflammasome activation
