Table 7.

Ratio of E=expected number of events over O=observed number of events (E/O) and standard deviations of Ē for simulations based on ViraHepC data with both markers IFNL4 and HCV-RNA with P(Y) = 0.1 based on n_cases = n_controls = 250.

	Overall		Race				IFNL4				HCV-RNA
Methods			Caucasian		Non-white		∆G/∆G or ∆G/TT		TT/TT		<median		≥median
	E/O (se)	sd(Ē)	E/O (se)	sd(Ē)	E/O (se)	sd(Ē)	E/O (se)	sd(Ē)	E/O (se)	sd(Ē)	E/O (se)	sd(Ē)	E/O (se)	sd(Ē)
Logistic new	1.089 (0.002)	0.0053	1.089 (0.002)	0.0109	1.089 (0.005)	0.0082	1.095 (0.003)	0.0058	1.084 (0.004)	0.0222	1.091 (0.003)	0.0109	1.086 (0.003)	0.0081
LR-joint	1.005 (0.001)	0.0030	1.008 (0.001)	0.0051	0.996 (0.001)	0.0018	0.992 (0.002)	0.0047	1.016 (0.003)	0.0182	1.004 (0.002)	0.0080	1.006 (0.003)	0.0070
LR-separate	1.078 (0.002)	0.0051	1.101 (0.002)	0.0083	1.011 (0.002)	0.0040	1.046 (0.003)	0.0053	1.107 (0.003)	0.0206	1.145 (0.004)	0.0138	0.993 (0.004)	0.0099
LR-ind	1.126 (0.002)	0.0052	1.233 (0.002)	0.0091	0.813 (0.002)	0.0030	0.944 (0.002)	0.0048	1.287 (0.004)	0.0214	1.168 (0.003)	0.0122	1.073 (0.003)	0.0087
LR-offset	1.084 (0.002)	0.0050	1.146 (0.002)	0.0087	0.902 (0.002)	0.0032	1.092 (0.003)	0.0059	1.077 (0.004)	0.0217	1.085 (0.003)	0.0108	1.082 (0.003)	0.0077
LR-shrink	1.089 (0.002)	0.0053	1.159 (0.002)	0.0093	0.884 (0.002)	0.0032	1.106 (0.003)	0.0061	1.075 (0.004)	0.0218	1.019 (0.003)	0.0106	1.180 (0.003)	0.0071
CML	1.006 (0.001)	0.0031	1.008 (0.001)	0.0052	1.001 (0.001)	0.0019	1.004 (0.002)	0.0048	1.008 (0.003)	0.0176	1.011 (0.002)	0.0088	1.000 (0.002)	0.0069