Table 1.
X | Compound | R | EC50 (μM) |
---|---|---|---|
S | 1 | 4-Cl | 1.93 |
2 | 2.6-diCl | 0.71 | |
3 | 3,5-diCl | 0.17 | |
SO | 4 | 4-Cl | > 32 |
5 | 4-Cl-2,5-diMe | 2.88 | |
SO2 | 6 | 4-Cl | 4.7 |
7 | 3,5-diCl | 1.41 | |
8 | 4-Cl-2,5-diMe | 1.47 | |
O | 9 | 4-Cl | 0.79 |
10 | 4-Et | 1.96 | |
11 | 3-Et | 0.72 | |
12 | 3-t-Bu | 0.87 | |
13 | 3,5-diCl | 0.067 | |
14 | 3,5-diCF3 | 0.58 | |
15 | 3,5-diF | 1.07 | |
16 | 3,5-diBr | 0.51 | |
17 | 3-Br | 1.02 | |
18 | 3-Ph | 2.84 | |
19 | 3,5-diPh | 3.70 |
Average Z’ factor value = 0.5