Skip to main content
. Author manuscript; available in PMC: 2021 Jun 7.
Published in final edited form as: J Med Chem. 2011 Dec 22;55(1):515–527. doi: 10.1021/jm2014277

Table 6.

Rat Plasma PK Profile of Compound 13a

AUC Last (ng × h/mL) AUC/Dose (ng × h/mL/dose) T1/2 (h) CL (mL/min/kg) Vss (L/kg) Cmax (ng/mL) Tmax (h) F (%)
i.v. 179 184 2.1 92 5.7 - - -
p.o. 42 50 3.6 - - 39 0.25 27
a

Single bolus administration of 1 mg/kg i.v. and p.o. to SD rats; data were obtained from Biogen Idec.