Table 6.
AUC Last (ng × h/mL) | AUC/Dose (ng × h/mL/dose) | T1/2 (h) | CL (mL/min/kg) | Vss (L/kg) | Cmax (ng/mL) | Tmax (h) | F (%) | |
---|---|---|---|---|---|---|---|---|
i.v. | 179 | 184 | 2.1 | 92 | 5.7 | - | - | - |
p.o. | 42 | 50 | 3.6 | - | - | 39 | 0.25 | 27 |
Single bolus administration of 1 mg/kg i.v. and p.o. to SD rats; data were obtained from Biogen Idec.