Table 2. Overview of selected biological roles of HDAC10 in non-tumor diseases.

Disease	Expression level	Functions	Targets/Signaling pathways	Cell lines/Tissues/Animal model	Reference
Eosinophilic airway inflammation	Elevated	Inhibit airway inflammation	IL-4, IL-5, IL-13	CD4+ CD45RBlow cell	[96]
TiO2-associated lung disease	Elevated	Cellular response	Reactive oxygen species	A549 cell	[97]
Emphysema	/	Pathogenic gene	Copy number gains	32 emphysema blood samples	[99]
IgAN	/	Chromatin modifying enzymes	/	8 IgAN blood samples and 9 normal blood samples	[101]
Renal fibrosis	Elevated	Regulate renal fibrosis	/	C57BL/6 male mice	[100]
Schizophrenia	/	Diagnostic value	/	278 Korean schizophrenia patients, 626 Caucasian schizophrenia parents	[102,103]
Post-ICH inflammation	Decreased	Aggravate inflammation response	PTPN22/NLRP3	6 ICH samples and S-D rat	[104]
Drug addiction	Elevated	Affect cognitive function	H4ac enrichment	C57BL/6 mice	[105]
Multiple sclerosis	Decreased	Affect oligodendrocytes	Oligo1 lysine 150 acetylation	Mouse neural progenitor cells, HEK293T cell	[108]
MTLE-HS	Elevated	Transcription regulation	/	28 MTLE-HS samples	[109]
LH secretion	Decreased	Reduce LH secretion	H3 acetylation	S-D rat	[110]
Melanogenesis	/	Promote melanogenesis	Pax3/KAP1	HEK293 cell and B16F10 cell	[111]
Adipogenesis	Decreased	Promote adipogenesis	H3K9 acetylation	MSCs	[114]
HIV infection	Decreased	Promote HIV infection	IN/LEDGF/p75, histone deacetylation	CD4+ T cell	[116,117]
Nutrition-associated growth	Elevated	Inhibit cell viability	mTOR, Hsp70, autophagy	S-D rat, Huh7 cell	[120]
TMJ inflammation	Decreased	Inhibit inflammatory response	IL-1β/NF-κB	13 TMJ samples	[121]

Abbreviations: ICH, intracerebral hemorrhage; IL, interleukin; IN, HIV-1 integrase; mTOR, mammalian target of rapamycin; NF-κB, nuclear factor κB; NLRP3, NOD-like receptors 3; PTPN22, protein tyrosine phosphatase nonreceptor type 22; TMJ, temporomandibular joint.