Table 1. Demographic information of the enrolled subjects.
| Parameter | Discovery cohort | Validation cohort | ||
|---|---|---|---|---|
| Patients with ACS (n=50) |
Healthy controls (n=50) |
Patients with ACS (n=120) |
Healthy controls (n=120) |
|
| Gender (female/male) | 10/40 | 10/40 | 43/77 | 51/69 |
| Age* (years) | 62.4 ± 13.1 | 56.8 ± 4.7 | 63.4 ± 13.5 | 53.3 ± 6.8 |
| BMI* (kg/m2) | 24.4 ± 3.4 | 23.8 ± 2.4 | 24.8 ± 3.4 | 24.3 ± 2.5 |
| Blood pressure* (systolic/diastolic) | 129.1 ± 21.3/78.5 ± 13.4 | 126.7 ± 13.7/77.8 ± 10.4 | 131.6 ± 23.6/79.2 ± 14.2 | 125.4 ± 13.8/76.6 ± 10.5 |
| Smoking (no/yes) | 27/23 | 18/32 | 57/63 | 70/50 |
| Diabetes mellitus (no/yes) | 33/17 | 50/0 | 72/48 | 117/3 |
| Hyperlipidemia (no/yes) | 25/25 | 48/2 | 48/72 | 117/3 |
| Hypertension (no/yes) | 22/28 | 50/0 | 53/67 | 120/0 |
| Familial CAD (no/yes) | 48/2 | 46/4 | 117/3 | 110/10 |
| Previous CABG (no/yes) | 50/0 | N/A | 119/1 | N/A |
| Previous PCI (no/yes) | 42/8 | N/A | 96/24 | N/A |
| LVEF* (%) | 53.8 ± 10.9 | N/A | 54.6 ± 11.0 | N/A |
| CK-MB* (ng/ml) | 32.6 ± 70.2 | N/A | 38.5 ± 66.1 | N/A |
| CRP* (mg/dl) | 0.3 ± 0.3 | N/A | 0.8 ± 2.1 | N/A |
| Glucose* (mg/dl) | 161.1 ± 76.2 | 91.4 ± 9.8 | 160.5 ± 75.8 | 94.0 ± 21.6 |
| LDL* (mg/dl) | 101.2 ± 35.7 | 128 ± 30.1 | 101.4 ± 37.4 | 126.6 ± 31.8 |
| Total cholesterol* (mg/dl) | 169.1 ± 36.0 | 208.9 ± 31.3 | 168.8 ± 39.3 | 208.4 ± 34.0 |
| Triglyceride* (mg/dl) | 144.1 ± 97.9 | 120.2 ± 50.0 | 154.0 ± 94.1 | 142.0 ± 84.3 |
| Troponin T* (ng/ml) | 600.5 ± 2398.8 | N/A | 1.3 ± 2.1 | N/A |
Abbreviations: CABG, coronary artery bypass graft; CK-MB, creatinine kinase-myocardial band; LVEF, left ventricular ejection fraction; PCI, percutaneous coronary intervention.
*Mean ± standard deviation.