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Bioavailability radar of EsA. The colored zone is the suitable physicochemical space for oral bioavailability. LIPO(Lipophilicity):−0.7 < ALOGP3 < +5.0; SIZE:150 g/mol < MV < 500 g/mol; POLAR(Polarity):20 Å2 < TPSA <130 Å2; INSOLU(Insolubility):0 < Log S (ESOL) < 6; INSATU (Insaturation):0.25 < Fraction Csp3 < 1; FLEX(Flexibility): 0 < Num.rotable bonds <9. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
