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[Preprint]. 2021 Jun 2:2021.05.31.21254851. [Version 1] doi: 10.1101/2021.05.31.21254851

Figure 5. EHR validation of computational drug repurposing.

Figure 5.

Top individual compounds (imiquimod, everolimus, azathioprine and retinol; left panel) and the top compound category (anti-HIV protease inhibitors; right panel) are evaluated to determine whether they are associated with a decreased likelihood for a positive SARS-CoV-2 test. For the individual compound analysis, all individuals that had a SARS-CoV-2 test and could be matched are considered (n=755,346). The number of individuals that tested positive vs. negative for SARS-CoV-2 are provided in the y-axis labels. For the top compound category (anti-HIV protease inhibitors), the group of those receiving anti-retroviral treatment with an anti-HIV protease inhibitor (n=1,105) are compared against those that are receiving other anti-HIV medications (n=5,450). The effect size (log(OR)) is plotted along with 95% CI error bars. ***, ** and * correspond to Bonferroni-adjusted association p values equal to, or less than, 0.001, 0.01 and 0.05, respectively.